This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 - Biomedical Research and Research Training, aims to advance the understanding of how homeodomain (HD) transcription factors (TFs) regulate gene expression and impact human health. The $510,390 award to the Children's Hospital Medical Center in Cincinnati, Ohio will fund a 5-year research program to investigate the mechanisms underlying HD TF DNA binding specificity, the functional impact of disease-associated HD variants, and the role of cooperative HD TF complexes in transcriptional regulation. The research will utilize a multidisciplinary approach including computational, biochemical, structural, cellular, genetic, and genomic methods, as well as Drosophila and human organoid models. This work is expected to provide new insights into the fundamental principles governing HD TF function and how variation in these crucial regulators contributes to human disease.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $510.4k | 5/7/25 |