Project Grant R01GM157834
- This federal Project Grant award of $667,480.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to St. Jude Children's Research Hospital Inc. The award supports fundamental scientific research and advanced training focused on understanding the regulation of genome expression by chromatin and how mutations in chromatin proteins contribute to oncogenesis. The research aims to provide new insights...
- This federal Project Grant award of $427,571.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports a research project titled "Maintenance of Cellular Memory During Replication" at the University of Colorado-Denver. The project aims to uncover the molecular determinants of cellular identity and how chromatin states are regulated across the cell cycle. Key objectives...
- This federal Project Grant award of $390,000.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to elucidate the mechanisms underlying DNA double-strand break repair at Thomas Jefferson University, doing business as Sidney Kimmel Medical College. The research aims to determine the regulatory mechanisms of the multi-protein and multi-step process required to coordinate the repair of DNA...
- This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the mechanisms and factors that promote aberrant DNA repair during meiosis, leading to the formation of de novo structural variants. The $380,495 award, with a project period from February 1, 2025 to January 31, 2030, will be performed by the Regents of the University of Michigan. The...
- The National Institute of Environmental Health Sciences (NIEHS) awarded a $616,715 Project Grant to the University of Southern California (USC) under the Environmental Health federal grant program (CFDA 93.113). The purpose of this 5-year grant, with a period of performance from August 1, 2025 to May 31, 2030, is to conduct research on the mechanisms by which nuclear actin filaments and phase separation promote faithful homologous recombination repair of double-strand breaks in heterochromatic...
- This federal Project Grant award of $617,007 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on the molecular mechanisms of DNA double-strand break repair through non-homologous end joining (NHEJ). The research aims to elucidate how DNA ends are held together and coordinated with end processing enzymes to maximize the fidelity of NHEJ and minimize genome alterations. The...
- The University of Southern California (USC) was awarded a $456,500 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health Federal Grant Program (CFDA 93.113). The funding supports a research project titled "DROSOPHILA NSE5/6: A MISSING LINK FOR HETEROCHROMATIN REPAIR", which aims to identify and characterize the Drosophila NSE5/6 protein and its functions in repairing double-strand DNA breaks within heterochromatin regions....
- This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $495,594.00 to the University of California, Santa Barbara to conduct research on the mechanisms underlying DNA double-strand break repair through homologous recombination. The objectives of this 5-year project are to 1) define the steps in recombination altered by DNA interstrand crosslinks, 2) explore how the DNA repair regulatory kinase ATR is activated during double-strand break...
- This federal Project Grant award of $1,943,750.00, awarded on August 8, 2025, is provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports fundamental research and advanced training focused on understanding the molecular mechanisms that regulate the mitotic DNA damage response. The project, led by researchers at The Washington University, aims to 1) reveal how ubiquitinated histone H2A acts...
- This Project Grant award of $254,919.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research at the University of California, San Diego (UCSD) to investigate the regulatory mechanisms that ensure accurate transmission of the genome during cell division. Specifically, the research aims to study how post-translational modification enzymes regulate the assembly and function of DNA replication...
This Project Grant award of $451,259.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to illuminate the role of chromatin composition and regulation in the repair of double-strand breaks in heterochromatin. The research, conducted by the University of Southern California, aims to: 1) establish the function of "silent" chromatin marks in promoting early heterochromatin repair; 2) identify chromatin changes and modifiers responsible for repair progression; and 3) define how damage-induced long non-coding RNAs contribute to heterochromatin repair. This work seeks to address a critical gap in understanding how misregulation of this pathway contributes to cancer initiation and progression, as well as how epigenetic therapies may impact cancer recurrence. The project will run from September 1, 2025 through June 30, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $451.3k | 8/29/25 |