Project Grant R35GM158238
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $541,967 to the University of Chicago to investigate the mechanical behaviors of cells and their impact on physiological processes and diseases. The research aims to expand the understanding of adherent cell mechanics and mechanobiology, focusing on the force-sensitive remodeling of cell-cell adhesions and the role of LIM...
- This federal Project Grant award of $329,976 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to establish a multiscale modeling strategy to simulate ion selectivity in proteins. The principal investigator will utilize novel force fields to conduct molecular dynamics simulations that provide structural, dynamic, and thermodynamic insights into protein-ion interactions. The research aims to analyze the...
- This federal Project Grant award of $294,147 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to advance modeling of macromolecular interactions in living cells. The key products and services to be delivered through this 5-year project (6/1/2025 - 5/31/2030) include: Characterization of the intermolecular energy landscapes for different types of macromolecules Simulation of macromolecular interactions...
- This Project Grant award of $501,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research by The Regents of the University of California, San Francisco (UCSF) to develop simulation-based models that can more accurately interpret experimental data in structural biology. The goal is to enhance understanding of how macromolecules communicate and interact, which is vital for advancing...
- The National Institute of General Medical Sciences (NIGMS) awarded a $534,450 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Chicago. The grant, effective July 1, 2025 through June 30, 2030, supports the university's "Dual-Mentored Training for Collaborative Molecular Biophysics" program. This program trains graduate students in an interdisciplinary curriculum combining the physical and life sciences, with each student...
- This federal Project Grant award of $150,104.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to develop a computational framework for investigating the dynamics of actin filament branch formation and aging. The research will focus on understanding the role of nucleotide state and ATP hydrolysis in the actin-related protein (Arp) 2 and Arp3 subunits of the Arp2/3 complex during branch formation,...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund a $540,000 research project at Northwestern University to measure the global folding stability and folding energy landscapes for 3 million protein sequences. The project aims to create a large dataset quantifying these properties, which have historically been challenging to investigate at scale. This data will empower...
- This Project Grant award of $638,334 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to advance the understanding of structural mechanisms underlying protein-small molecule binding and protein function. The project will develop novel computational methods for thermodynamic mapping of proteins, ligands, and surrounding aqueous solvent using molecular dynamics simulations. The goal is to create a...
- The National Institute of General Medical Sciences (NIGMS) awarded a $2,041,875 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Board of Regents of the University of Nebraska. The project aims to utilize cutting-edge live-cell single molecule tracking, super-resolution microscopy, and CRISPR-Cas9 gene editing technologies to unravel the regulation of the Arp2/3 actin assembly complex and its role in cellular processes such as lamellipodial...
- The University of Chicago was awarded a $1,906,969.00 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) by the National Institutes of Health to conduct research on the molecular basis for myosin-10 regulation. The proposed study aims to investigate how ligand binding, myosin quaternary structure, and actin filament architecture influence the motility of myosin-10, a motor protein critical for cellular processes like intracellular trafficking, cell...
This $1,970,835 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research at the University of Chicago focused on the multiscale simulation of key biomolecular processes in the cell. The project will employ bottom-up coarse-grained computational models to study protein-protein interactions, protein-mediated membrane remodeling, and the formation and remodeling of actin-based networks, which are critical to cellular processes like endocytosis, immune response, and cellular motility. The research will develop and apply novel multiscale computational methods to investigate the propagation of molecular-level interactions to the collective behavior at the cellular level. This 4-year project began on September 15, 2025 and is scheduled for completion by August 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.0m | 9/11/25 |