The University of Chicago received a $541,967 project grant award from the National Institute of General Medical Sciences (NIGMS), through the Biomedical Research and Research Training program (CFDA 93.859), to expand the understanding of adherent cell mechanics and mechanobiology. The 5-year award will support research to investigate the force-sensitive remodeling of cell-cell adhesions and the role it plays in contact inhibition of proliferation, as well as mechanisms of mechanosensing via LIM domain proteins within the actin cytoskeleton. The project aims to develop new experimental approaches and data-driven biophysics modeling to probe the mechanochemical circuitry within cells, with the goal of broadly impacting the field of cellular biophysics and mechanobiology.
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