Project Grant R35GM159986
- This Project Grant award of $501,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research by The Regents of the University of California, San Francisco (UCSF) to develop simulation-based models that can more accurately interpret experimental data in structural biology. The goal is to enhance understanding of how macromolecules communicate and interact, which is vital for advancing...
- The National Institute of General Medical Sciences (NIGMS) awarded a $1,479,729 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of California, doing business as the University of California, Berkeley (UC Berkeley). The goal of this 5-year program is to discover new synthetic strategies and concepts to rapidly prepare biologically important and structurally complex molecules, particularly from the Euphorbiaceae and...
- The National Institute of General Medical Sciences (NIGMS) awarded a $361,952 project grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of California, doing business as the University of California, Berkeley (UC Berkeley). The grant supports research to systematically explore the mutational landscape of biomedically relevant proteins such as CRISPR-Cas genome editing enzymes. The goal is to develop experimental methods and machine...
- This Project Grant award of $638,334 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to advance the understanding of structural mechanisms underlying protein-small molecule binding and protein function. The project will develop novel computational methods for thermodynamic mapping of proteins, ligands, and surrounding aqueous solvent using molecular dynamics simulations. The goal is to create a...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program focused on understanding the relationship between the structure and function of organic solid-state materials, with a specific emphasis on drug polymorphism, physicochemical properties, and crystallization mechanisms. The $411,454 award, with a performance period from August 1, 2025 to May 31, 2030, will...
- This federal Project Grant award of $151,040.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of California, doing business as the University of California, Berkeley. The funding supports research to develop supramolecular photocatalysts that can enable novel photochemical reactions to produce oxygen- and nitrogen-containing heterocycles in a highly selective...
- This $254,182 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will fund the development of a novel, unified X-ray/cryo-EM pipeline for ensemble-based structural refinement. The project aims to address the significant challenges posed by structural disorder, flexibility, and conformational heterogeneity in modern therapeutic modalities, which limit the accuracy of traditional refinement...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop state-of-the-art software tools capable of accurately modeling bound drug molecules in receptor structures from cryo-electron microscopy (cryo-EM) data with resolutions up to 5-6 Angstroms. The $217,941 award to Molecular Intelligence LLC, a small business, will run from September 1, 2025 to February 28, 2027. This...
- This $1,444,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop new cryogenic electron microscopy (cryo-EM) methods to visualize the structural heterogeneity of ribosomes at the single-molecule level in cells. The award, effective September 2, 2024 through August 31, 2027, will enable the principal investigator to pursue strategies to extend a novel technique called 2D template...
- This $395,455 Project Grant was awarded on August 1, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The goal of the project is to develop and apply computational methods for biomolecular structural modeling using cryo-electron microscopy (cryo-EM) data. Key products and services to be delivered include: Expanding and enhancing the capabilities of structure modeling methods to improve accuracy and...
The National Institute of General Medical Sciences (NIGMS) awarded a $401,250 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of California, Berkeley (UC Berkeley). The grant, with a performance period from September 15, 2025 to July 31, 2030, aims to develop a computational framework that can reliably predict the solubility of drug-related molecular crystals. This effort will involve creating efficient machine learning potentials based on quantum mechanical calculations, enhancing crystal structure predictions using generative models, and building an automated workflow for high-throughput solubility computations. The project also seeks to develop data-driven models to improve the accuracy of informatics-based solubility predictions, which will be validated against publicly available datasets and tested using blinded data for newly synthesized compounds. The goal is to create a computational platform that can transform drug discovery by enabling reliable predictions of key molecular properties.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $401.3k | 9/10/25 |