Project Grant R43GM161135
- This $254,182 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will fund the development of a novel, unified X-ray/cryo-EM pipeline for ensemble-based structural refinement. The project aims to address the significant challenges posed by structural disorder, flexibility, and conformational heterogeneity in modern therapeutic modalities, which limit the accuracy of traditional refinement...
- This $395,455 Project Grant was awarded on August 1, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The goal of the project is to develop and apply computational methods for biomolecular structural modeling using cryo-electron microscopy (cryo-EM) data. Key products and services to be delivered include: Expanding and enhancing the capabilities of structure modeling methods to improve accuracy and...
- The National Institute of General Medical Sciences (NIGMS) awarded a $202,467 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Acpharis, a biotechnology software company based in Holliston, Massachusetts. The grant supports the development of a commercial-quality software product that integrates machine learning with physics-based computational approaches to accurately predict the structures of antibody-antigen complexes. This breakthrough technology,...
- This Project Grant award of $638,334 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to advance the understanding of structural mechanisms underlying protein-small molecule binding and protein function. The project will develop novel computational methods for thermodynamic mapping of proteins, ligands, and surrounding aqueous solvent using molecular dynamics simulations. The goal is to create a...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $349,999 to Denovx, LLC to adapt the company's surface science approach to improving protein crystallization for enhancing cryogenic electron microscopy (cryo-EM) specimen quality. The goal is to identify physical and chemical modifications to cryo-EM support materials that can enhance the adsorption and random orientation of...
- This Project Grant award of $306,872.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), aims to develop a new 3D shape matching methodology that accounts for water molecules when comparing ligands during drug discovery. The key products and services to be delivered include: Adapting an existing algorithm (WATGEN) to predict water positions in unbound proteins and protein-ligand complexes, and calculate...
- The federal Project Grant award of $338,843 was provided by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), to Nanoengineering Corporation (UEI: SL7BYLYTR6A1) for the project "Soft-Landing of Size-Separated Macromolecules for Structural Analysis by Cryo-TEM". The project aims to develop an electrospray differential mobility analysis (ES-DMA) soft landing system to enable higher-resolution cryogenic...
- This $1,444,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop new cryogenic electron microscopy (cryo-EM) methods to visualize the structural heterogeneity of ribosomes at the single-molecule level in cells. The award, effective September 2, 2024 through August 31, 2027, will enable the principal investigator to pursue strategies to extend a novel technique called 2D template...
- This $380,785 Project Grant was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to Cornell University. The grant supports research to develop new algorithms for quantitatively recovering protein conformational ensembles from cryogenic electron microscopy (cryo-EM) data. The key objectives are to accelerate computational methods for matching simulated and experimental cryo-EM images, and to utilize...
- The National Institutes of Health (NIH) awarded a $1,476,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to The Trustees of Princeton University for a project titled "Algorithms and Software for Biomolecular Structure Determination at the Proteome Scale". The objective of this 3-year project, starting on September 9, 2025 and ending on August 31, 2028, is to develop novel artificial intelligence (AI) and machine learning (ML) methods to address critical...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop state-of-the-art software tools capable of accurately modeling bound drug molecules in receptor structures from cryo-electron microscopy (cryo-EM) data with resolutions up to 5-6 Angstroms. The $217,941 award to Molecular Intelligence LLC, a small business, will run from September 1, 2025 to February 28, 2027. This technology is expected to accelerate drug discovery and development by providing precise structural information to guide the design of molecules with improved efficacy and reduced off-target effects, ultimately advancing the field of precision medicine.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/23/25 | ||
| Not listed | $217.9k | 7/29/25 |