Project Grant R44GM163476
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop state-of-the-art software tools capable of accurately modeling bound drug molecules in receptor structures from cryo-electron microscopy (cryo-EM) data with resolutions up to 5-6 Angstroms. The $217,941 award to Molecular Intelligence LLC, a small business, will run from September 1, 2025 to February 28, 2027. This...
- This $395,455 Project Grant was awarded on August 1, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The goal of the project is to develop and apply computational methods for biomolecular structural modeling using cryo-electron microscopy (cryo-EM) data. Key products and services to be delivered include: Expanding and enhancing the capabilities of structure modeling methods to improve accuracy and...
- This $1,444,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop new cryogenic electron microscopy (cryo-EM) methods to visualize the structural heterogeneity of ribosomes at the single-molecule level in cells. The award, effective September 2, 2024 through August 31, 2027, will enable the principal investigator to pursue strategies to extend a novel technique called 2D template...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $349,999 to Denovx, LLC to adapt the company's surface science approach to improving protein crystallization for enhancing cryogenic electron microscopy (cryo-EM) specimen quality. The goal is to identify physical and chemical modifications to cryo-EM support materials that can enhance the adsorption and random orientation of...
- This Project Grant award of $501,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research by The Regents of the University of California, San Francisco (UCSF) to develop simulation-based models that can more accurately interpret experimental data in structural biology. The goal is to enhance understanding of how macromolecules communicate and interact, which is vital for advancing...
- This $380,785 Project Grant was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to Cornell University. The grant supports research to develop new algorithms for quantitatively recovering protein conformational ensembles from cryogenic electron microscopy (cryo-EM) data. The key objectives are to accelerate computational methods for matching simulated and experimental cryo-EM images, and to utilize...
- This $361,283 Project Grant award, provided by the U.S. Department of Health and Human Services' National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 Biomedical Research and Research Training, supports research at Yale University focused on advancing the fields of molecular structure analysis and molecular dynamics simulations. The research aims to develop novel methods and algorithms that leverage cutting-edge techniques like cryo-electron microscopy and molecular...
- This Project Grant award of $638,334 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to advance the understanding of structural mechanisms underlying protein-small molecule binding and protein function. The project will develop novel computational methods for thermodynamic mapping of proteins, ligands, and surrounding aqueous solvent using molecular dynamics simulations. The goal is to create a...
- This $436,361 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative computational tools and algorithms to advance small-angle and wide-angle X-ray scattering (SWAXS) analysis for studying the structure and dynamics of biological macromolecules. The key objectives of this 5-year project include: 1) Improving the resolution of density reconstructions...
- The National Institutes of Health (NIH) awarded a $1,476,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to The Trustees of Princeton University for a project titled "Algorithms and Software for Biomolecular Structure Determination at the Proteome Scale". The objective of this 3-year project, starting on September 9, 2025 and ending on August 31, 2028, is to develop novel artificial intelligence (AI) and machine learning (ML) methods to address critical...
This $254,182 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will fund the development of a novel, unified X-ray/cryo-EM pipeline for ensemble-based structural refinement. The project aims to address the significant challenges posed by structural disorder, flexibility, and conformational heterogeneity in modern therapeutic modalities, which limit the accuracy of traditional refinement methods. The proposed approach will integrate robust, linear-scaling QM/MM methods with enhanced density-driven molecular dynamics to more accurately model these complex systems, thereby improving the quality of experimental structural data and supporting advancements in drug discovery and development. The project will be conducted by Quantumbio Inc. and is scheduled for completion by March 31, 2026.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/19/25 | ||
| Not listed | $254.2k | 9/17/25 |