The National Institute of General Medical Sciences (NIGMS) awarded a $344,400 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The University of Texas Southwestern Medical Center to develop new tools and approaches for improving cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) imaging techniques. Specifically, the grant aims to: 1) Develop a sample preparation strategy to reduce electron-induced radiolysis of frozen-hydrated biological...
This Project Grant awarded by the National Science Foundation (CFDA 47.074 - Biological Sciences) provides $980,943 to Purdue University to develop new artificial intelligence (AI) tools for interpreting cryogenic electron microscopy (cryo-EM) data into accurate 3D molecular structures and assessing their quality. The key objectives are to: (1) create a deep learning-based method for constructing protein-DNA/RNA complex structures and identifying unknown proteins and nucleic acids in cryo-EM...
This $1,444,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop new cryogenic electron microscopy (cryo-EM) methods to visualize the structural heterogeneity of ribosomes at the single-molecule level in cells. The award, effective September 2, 2024 through August 31, 2027, will enable the principal investigator to pursue strategies to extend a novel technique called 2D template...
The National Institute of General Medical Sciences (NIGMS) has awarded a $294,147 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) program to the University of Kansas Center for Research Inc. The 5-year grant, effective June 1, 2025, will support the development of advanced computational modeling approaches to characterize macromolecular interactions within living cells. The project aims to bridge classical docking and biomolecular simulation methods to enable...
The National Institute of General Medical Sciences (NIGMS) awarded a $752,456 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Pittsburgh. The grant, effective September 1, 2024 through July 31, 2029, supports the development and application of innovative, user-friendly computational technologies for identifying new bioactive small molecules and improving their pharmacological properties. Key focus areas include creating a database of...
The National Institute of General Medical Sciences (NIGMS) awarded a $291,224 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Chicago to develop BRAVE-EM, a novel imaging technique that combines the wavelength specificity of optical light microscopy with the spatial resolution and volume imaging capabilities of electron microscopy. This 5-year research program, starting on August 15, 2024, seeks to enable simultaneous functional and structural imaging...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $792,584 to Old Dominion University and its affiliated research foundation to develop multi-resolution docking methods and computational modeling tools for cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET). The 5-year project aims to advance flexible fitting and refinement of AlphaFold2 models, improve...
The National Institute of General Medical Sciences (NIGMS) awarded a $306,872 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Sindri Materials Corp, a for-profit veteran-owned manufacturer, to investigate the development of an optimized graphene-based architecture for cryogenic electron microscopy (cryo-EM) to address challenges in macromolecule imaging. The goal is to create a reliable, reproducible, and rapid cryo-EM integration solution using...
The National Institute of General Medical Sciences (NIGMS) awarded a $356,423 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) program to Duke University, a leading private research institution. The grant, with a performance period from May 15, 2025 to February 28, 2030, supports three key research directions: (A) Developing efficient and accurate quantum mechanical (QM) methods based on density functional theory (DFT) for modeling biological systems. (B)...
The National Institute of General Medical Sciences (NIGMS) awarded Vanderbilt University a $395,943 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) with a performance period from September 1, 2024 to August 31, 2029. The goal of this research program is to develop new spectroscopic methods capable of providing enhanced insight into protein structure and dynamics within complex environments that impact human health. The key products and services to be...