The National Institute of General Medical Sciences (NIGMS) awarded a $984,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The University of Texas Southwestern Medical Center to support research focused on "Expanding Access to Molecular Complexity through Natural Product Synthesis." The project aims to develop new tools and strategies for the synthesis of complex natural products, which can serve as vital medicines and advance the field of organic...
This Project Grant award, valued at $1,170,000.00 and funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop new synthetic methods and strategies for the scalable production of complex bioactive natural and unnatural compounds. The key objectives are to: (a) devise new catalytic stereoselective approaches for generating densely substituted polycyclic building blocks, (b) design...
This $289,424 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to expand the synthetic biology toolset for natural products discovery from myxobacteria. The long-term objective is to increase the number of heterologous host chassis and develop novel strategies to generate host platforms to utilize biosynthetic gene clusters (BGCs) for discovering new bacterial metabolites with...
This National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) Project Grant award of $800,308 supports research to engineer promiscuous enzymes for the synthesis of biological building blocks. The research aims to: 1) conduct mechanistic analysis of pyridoxal-phosphate dependent enzymes that catalyze C-C bond formation, to enable hypothesis-driven strategies to improve enzyme function, and 2) explore new strategies to increase the...
The National Institute of General Medical Sciences (NIGMS) awarded a $329,616 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Emory University in Atlanta, Georgia. This 5-year grant, effective July 1, 2024, will support the "Biological Discovery Through Chemical Innovation Training Program (BDCI TP)". This new, innovative predoctoral training program at Emory University aims to provide specialized, interdisciplinary education in chemistry,...
The National Institute of General Medical Sciences (NIGMS) awarded a $524,400 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to the Scripps Research Institute in La Jolla, CA. The grant will fund research to develop novel transformations and catalysts that enable "universal functionalization" of carbon-carbon double and triple bonds. This will expedite the synthesis of structurally complex small molecules for drug discovery and production. The...
This $360,100 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research on novel synthetic methods using supramolecular catalysis to enable pharmaceutical-relevant transformations. The principal investigator at the University of California, Berkeley will develop methods for N-heterocycle reduction, olefin epoxidation, and enantioselective C(sp3)-H oxidation of alkanes....
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the development of efficient and accurate methods for identifying novel natural product small molecules from complex mass spectral datasets. The $275,484 award, which began on Sep 1, 2023 and runs through Aug 31, 2024, will enable the grantee, Chemia Biosciences, Inc., to integrate genome mining with computational metabolomics to...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research focused on investigating the biosynthesis of labdane-related diterpenoid natural products. The $401,595 award, effective from February 1, 2025 to January 31, 2030, will be performed by Iowa State University of Science and Technology. The research aims to advance the understanding of the enzymes and metabolic pathways...
The National Institute of General Medical Sciences (NIGMS) awarded Vanderbilt University a 5-year, $395,881 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to develop new protocols for altering the molecular topology of biologically active natural products and therapeutic compounds. The key products to be delivered through this grant include: 1) Photochemical deconstructive epimerization protocols involving C-C bond cleavage, radical intermediate formation, and C-C bond...