The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant (CFDA 93.859 - Biomedical Research and Research Training) totaling $667,480 to St. Jude Children's Research Hospital Inc. The grant, which runs from May 1, 2025 to April 30, 2030, supports research to understand the dynamics of active and silent chromatin states, including the biology of repetitive elements and the mechanisms of chromatin dynamics and modifications. The research combines structural biology,...
The National Institute of General Medical Sciences (NIGMS) awarded a $294,647 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to the University of Texas at Dallas (UTD). The grant will fund a 4-year project from September 1, 2024 to August 31, 2028 to develop a theoretical, computational, and experimental framework for modeling epigenetic regulatory networks in human cells. The key objectives are to rapidly assemble and stably integrate libraries of...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $2,720,800.00 in funding to Brigham & Women's Hospital Inc. over a period of 5 years, from July 5, 2024 to May 31, 2029. The award supports research focused on understanding the epigenetic regulation of transcriptional programming, with a particular emphasis on investigating the dynamic competition between Polycomb (PcG) and...
This Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the spatiotemporal regulation of epigenetic silencing by macromolecular interactions. The $1,271,250 award, effective from August 1, 2024 to May 31, 2029, will be performed by Weill Medical College of Cornell University in New York City. The research aims to elucidate how a critical histone...
This Project Grant award of $462,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to establish the epigenetic mechanisms of gene regulation that govern the biology of embryonic stem cells (ESCs). The research aims to: 1) Dissect the molecular and biological requirements of TET-driven DNA hydroxylation versus formylation/carboxylation in ESC biology; and 2) Identify readers...
This federal Project Grant award, R35GM153238, is funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The $890,066 award, effective from Sep 2, 2024 to Jul 31, 2029, supports research to identify the genetic instructions and processes that regulate long-distance interactions between enhancers and promoters, which are critical for controlling gene expression patterns during embryonic development and in...
This Project Grant award of $515,504.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate the role of phase separation in transcriptional regulation in yeast. The project will examine how transcription factors, coactivators, and DNA interact to undergo phase separation, and whether transcriptional activity is driven by small complexes or phase-separated condensates. Additionally, the...
This $899,100 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate developmental constraints shaping human sex chromosomes and the mechanisms of X chromosome inactivation (XCI) escape. The award will enable the development of human induced pluripotent stem cell (hIPSC) lines to model monosomy-X (Turner syndrome) and study how specific X/Y gene pairs and...
This Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the role of DNA methylation in controlling retrotransposons and governing adult stem cell fates. The $1,226,250 award to The University of Texas MD Anderson Cancer Center will fund a 5-year research project focused on elucidating the molecular mechanisms by which DNA methylation regulates...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $504,175 in funding to Yale University to support research on the role of non-coding RNA in regulating pluripotent stem cell biology and differentiation. The research program leverages the planarian Schmidtea mediterranea as a model system to investigate how PIWI-interacting RNAs (piRNAs) and their associated proteins regulate chromatin...