This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $515,504 to St. Jude Children's Research Hospital Inc. to conduct research on the role of phase separation in the regulation of transcription. The research aims to understand how transcription factors, coactivators, and DNA interact and phase separate together, and how this impacts transcriptional activity and function. The researchers will generate separation-of-function mutants and quantify the driving forces for phase separation, combining expertise in transcription regulation and phase separation dynamics. Key objectives include elucidating the contributions of small complexes versus phase-separated condensates to transcriptional activity, and identifying how the emergent properties of condensates influence transcriptional regulation. The award period runs from September 1, 2024 through July 31, 2028. This research has high relevance for understanding the fundamental biology of transcription and potential therapeutic applications targeting transcriptional condensates.
Generated 3/4/25, 2:51 AM