The National Institute of General Medical Sciences (NIGMS) awarded a $125,000 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to the Whitehead Institute for Biomedical Research, a non-profit research institute in Cambridge, MA. The grant, awarded from January 1, 2025 to December 31, 2026, will support a research project titled "Combinatorial Signal Integration in the Maintenance and Renewal of Adult Germline Stem Cell Fate." The research aims...
This federal Project Grant award for $387,500.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to understand the roles of microRNAs in animal development. The long-term goal of this research program is to elucidate the gene regulatory mechanisms that enable a single-celled zygote to develop into a multicellular organism. Specifically, the project focuses on studying the...
This $148,568 Project Grant was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to the President and Fellows of Harvard College. The grant aims to investigate the developmental origins and chromatin landscape of adult pluripotent stem cells in the regenerative species Hofstenia. The research seeks to identify the genetic components and gene regulatory networks that establish and maintain these stem...
This $380,546 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) supports research to define how post-transcriptional regulation of gene expression shapes the function of spermatogonial stem and progenitor cells in the mouse model. The key objectives are to: 1) Investigate how the RNA-binding protein DAZL enhances retinoic acid-mediated transcriptional and translational changes to induce...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $1,102,648.00 to The Trustees of Columbia University in the City of New York to conduct research on how the dynamic molecular interactions of RNA binding proteins (RBPs) drive post-transcriptional gene expression changes during embryonic stem cell differentiation. The research aims to globally map protein-protein interactions,...
This $1,226,250 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate the role of DNA methylation in regulating retrotransposons and governing adult stem cell fate decisions. The award to the University of Texas MD Anderson Cancer Center will fund a 5-year study using mouse skin as a model system to: (1) elucidate the molecular mechanisms underlying DNA and...
The National Institute of General Medical Sciences (NIGMS) awarded a $124,767 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of California, San Francisco (UCSF). The grant, with a performance period from September 10, 2024 to July 31, 2026, will support research into the mechanisms of cellular patterning through RNA regionalization and spatial genome organization in the unicellular organism Stentor coeruleus. Specifically,...
This $205,625 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to study the role of the NSUN2 RNA methyltransferase in regulating translation and pluripotency in stem cells. The award to The Trustees of Columbia University will fund two aims: 1) Identify NSUN2 and YBX1 RNA methylation targets for translational control of stem cell pluripotency, and...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $899,100 to the University of Connecticut Health Center (UCHC) from August 1, 2024 to July 31, 2029. The award supports research to characterize the mechanisms of X chromosome inactivation, escape, and reactivation in human induced pluripotent stem cells (hiPSCs). The research aims to elucidate how specific X and Y...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $785,000 in funding to Rutgers, The State University to investigate RNA-mediated chromatin regulation and transgenerational epigenetic inheritance in C. elegans. The key objectives are to: 1) Determine the functional relationship between three key heterochromatin histone modifications and understand the role of the nuclear...