This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $541,967 to the University of Chicago to investigate the mechanical behaviors of cells and their impact on physiological processes and diseases. The research aims to expand the understanding of adherent cell mechanics and mechanobiology, focusing on the force-sensitive remodeling of cell-cell adhesions and the role of LIM...
The University of California Irvine will use a $2.83 million project grant from the Department of Health and Human Services' National Institute of General Medical Sciences to decipher the mechanism of long-range gene regulation in vivo. Over a three-year period ending August 2025, UC Irvine researchers will utilize efficient enhancer replacement technology in mice to systematically characterize long-range enhancer activity and identify cis-regulatory sequences critical to this function. A...
The National Institute of General Medical Sciences (NIGMS) awarded a $715,109 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Illinois to uncover novel heme chemistry in microbial systems. The research aims to establish how divergent bacterial diheme proteins stabilize high-valent bis-FeIV states and utilize these intermediates for site-specific substrate oxidation. Key objectives include addressing outstanding questions related to the...
The National Institute of General Medical Sciences (NIGMS) awarded a $427,571 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of Colorado, doing business as the University of Colorado-Denver. The award, which runs from January 15, 2025 to December 31, 2029, will support research to uncover the molecular determinants of cellular identity and the regulation of chromatin states across the cell cycle. Specifically, the...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research at Northwestern University on how RNA modifications regulate translation initiation and cellular stress responses. The $440,000 award, effective August 1, 2025 through May 31, 2030, will integrate biochemistry, chemical biology, transcriptomics, and cell biology approaches to investigate how the epitranscriptome...
The University of Chicago was awarded a $435,126 Project Grant by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) federal grant program. The grant, which runs from January 20, 2025 to December 31, 2029, supports the Rust Lab's research to understand the biophysical basis of circadian rhythms and their connection to metabolism and fitness. Key research activities include leveraging a bacterial model system to investigate...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) will provide $108,793 to the University of Chicago to support structural and functional characterization of Cadherin EGF Laminin G Seven-Pass G-Type Receptors (Celsrs or Adgrcs), a family of adhesion G protein-coupled receptors (AGPCRs) that are essential for animal development. The research aims to determine the structural basis for...
The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $780,000 Project Grant to Oregon Health & Science University (OHSU) effective September 1, 2024 through July 31, 2029. The grant supports the development of innovative proteomic tools to study transcription factor-coregulator interactions and their role in gene regulation, cellular differentiation, and disease progression. Key objectives include...
The National Institute of General Medical Sciences (NIGMS) awarded a $268,734 Project Grant (CFDA 93.859 Biomedical Research and Research Training) to the University of Chicago for the "SHE (SUMMER HEALTHCARE EXPERIENCE) IN ONCOLOGY" program. This virtual, multi-institutional STEM enrichment program aims to increase participation of women from underrepresented backgrounds in the cancer biomedical workforce. The program provides high school students with hands-on research experience,...
This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,335,099 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) federal grant program to the University of Chicago. The 5-year award, effective September 2, 2024, will support research to identify the genetic instructions and processes that regulate long-distance interactions between enhancers and promoters, which are critical for gene expression control and have implications for human health. The research initiative will leverage large-scale genome engineering in human cells and mouse models, innovative genomic screens, and quantitative analyses to shed light on this understudied layer of genome regulation. The findings are expected to improve the ability to predict the impact of non-coding and structural genomic variants and enable the design of synthetic approaches to regulate enhancer-promoter interactions.