Project Grant R35GM158272
Award Date
6/1/25
Completion Date
4/30/30
Dollars Obligated
$375K
Federal Agency
National Institute of General Medical Sciences
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Texas, USA
Similar Awards
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training Program provides $440,000.00 to the University of Texas Medical Branch at Galveston (UTMB) over a period from May 15, 2025 to February 28, 2030. The award supports two research subprojects: The first subproject aims to build a quantitative understanding of how contractile injection systems, such as phage tails and tailocins, breach bacterial...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $316,968.00 to Emory University to study the regulation, inhibition, and quality control mechanisms of ribosomes, which are the cellular machinery responsible for protein synthesis. The research focuses on three key themes: 1) understanding translation fidelity events like miscoding, quality control, and mRNA frameshifting; 2)...
This $403,423 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate the molecular mechanisms of antibiotic inhibition of ribosomal subunit joining in bacteria. The project aims to characterize the kinetic, thermodynamic, and structural dynamics of the subunit joining process and elucidate how antibiotics impact these parameters. The research comprises three...
This $449,625 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support computational and experimental research at the University of Texas MD Anderson Cancer Center. The overarching goal is to develop advanced approaches to systematically identify and characterize the functions, regulation, and protein-protein interactions of "hidden" open reading frames (ORFs) that...
The National Institute of General Medical Sciences (NIGMS) awarded a $370,086 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Texas A&M University in College Station, Texas. The grant, effective from July 1, 2024 to June 30, 2029, aims to leverage single-molecule microscopy techniques to gain a detailed molecular-level understanding of type IV pili (TFP) in the opportunistic pathogen Pseudomonas aeruginosa. Specifically, the research will: 1) Use...
This $1,003,736 federal Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to expand the understanding of post-transcriptional regulation of gene expression in bacteria. The research program has two main sub-projects: 1) Investigating epitranscriptomic regulation of gene expression across various bacterial species, and 2) Exploring the regulatory roles of novel...
This federal Project Grant award of $401,253 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to elucidate novel cyclic nucleotide signaling pathways and physiological effects in bacteria. The research program aims to investigate the molecular mechanisms that control 2',3'-cyclic nucleotide monophosphate (2',3'-cNMP) signaling in bacteria, including its effects on transcription,...
This $392,500 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to mechanistically characterize the enzymology of human ribosome biogenesis. The 5-year project aims to fill a knowledge gap in understanding the molecular mechanisms underlying ribosome biogenesis, which is among the most energetically costly cellular processes and is dysregulated in ribosomopathies and...
This $462,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to decipher the genetic regulation of bacterial heterogeneity in response to antibiotic stress using single-cell transcriptomics. The research, conducted at St. Jude Children's Research Hospital, will employ bacterial single-cell RNA sequencing technology to map the genetic factors driving bacterial heterogeneity and elucidate...
This federal Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to investigate the mechanisms underlying lipoprotein trafficking to the bacterial outer membrane. The award, totaling $440,327.00, is for the period from January 27, 2025 to December 31, 2029. The primary research objectives are to uncover the factors responsible for lipoprotein trafficking in the...