Project Grant R35GM156417

Award Date 1/1/25
Completion Date 11/30/29
Dollars Obligated $450K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Houston, TX 77030, USA
Similar Awards
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) totals $408,750 and is effective from September 15, 2024 through July 31, 2029. The award will support the development of large-scale composite hypothesis testing approaches for performing translational genetics analyses. Specifically, the research will focus on creating interpretable and robust statistical methods for...
This Project Grant award, valued at $936,000.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) federal grant program. The goal of this project is to develop a platform called mRNADesigner, an integrated deep learning model to optimize the 5'UTR, codon usage, and 3'UTR of mRNA sequences simultaneously. This will enable users to design optimal mRNA sequences to enhance protein expression levels and...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research at Northwestern University on how RNA modifications regulate translation initiation and cellular stress responses. The $440,000 award, effective August 1, 2025 through May 31, 2030, will integrate biochemistry, chemical biology, transcriptomics, and cell biology approaches to investigate how the epitranscriptome...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,215,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The University of Texas M.D. Anderson Cancer Center. The grant, effective September 1, 2024 through July 31, 2029, will support a functional analysis of arginine methylation, a common post-translational modification. The research aims to broadly understand the biological roles of arginine methylation, identify novel effector proteins that...
The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training federal grant program (CFDA 93.859), awarded a $675,898 Project Grant to The University of Texas Southwestern Medical Center (UT Southwestern) to conduct research on defining the modular architecture of protein intrinsically disordered regions (IDRs) for a predictive understanding of biological function. The 5-year grant, starting on Sep 1, 2024, will use computational approaches, in...
This federal Project Grant award of $597,573 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports structural and dynamic studies of large protein and protein-nucleic acid complexes and assemblies that play key roles in human health and disease. The primary objectives are to: (1) provide atomic-resolution insights into the structure, dynamics, interactions, and function of nucleosomes and large nucleosome arrays...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $812,500 in funding to The Trustees of the University of Pennsylvania (UPenn) to conduct research on RNA regulation and noncanonical translation between cell states. The research aims to map post-transcriptional regulation and the unannotated proteome, including RNA localization and modifications, to better understand how...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $1,301,595.00 in funding to Yale University to conduct research on a class of recently discovered human genes called internal open reading frames (iorfs). The project aims to: 1) use long-read sequencing to identify and validate the existence of iorf-encoding alternative transcripts in human cells, 2) provide...
This federal Project Grant award of $536,250.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop computational methods that can better identify and analyze rare cell populations from single-cell transcriptomic data. The project, titled "A Knowledge-Guided Analysis Approach to Recovering Rare Signals from Single-Cell Transcriptomic Data," will be conducted by the Sanford...
This federal Project Grant award of $644,900.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research on PAS (Period-ARNT-Single-Minded) domain proteins. The research aims to obtain mechanistic insights into how these ubiquitous signaling proteins, found across all kingdoms of life, detect and respond to changes in environmental conditions. Specifically, the research will utilize...

This federal Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) provides $449,625 to The University of Texas M.D. Anderson Cancer Center to develop and apply advanced computational and experimental approaches to systematically identify and study the functions, mechanisms, and regulation of "hidden" open reading frames (ORFs) that produce unconventional proteins. The research aims to contribute novel computational tools for modeling translation initiation and identifying new protein-protein interactions, as well as provide biological insights into the roles of these hidden ORF-derived proteins in development, physiology, and disease. The project period runs from January 1, 2025 to November 30, 2029.

Generated 8/5/25, 5:12 AM