This $300,477 federal Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The award will support a 5-year research project focused on investigating the molecular regulation of cell protrusion function in 3D environments. The research aims to develop computational algorithms based on computational geometry to reconstruct plasma membrane organization from 3D microscopy images and...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $541,967 to the University of Chicago to investigate the mechanical behaviors of cells and their impact on physiological processes and diseases. The research aims to expand the understanding of adherent cell mechanics and mechanobiology, focusing on the force-sensitive remodeling of cell-cell adhesions and the role of LIM...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $577,280.00 in funding to Northwestern University to support research on the signaling and metabolic regulation of nucleotide metabolism and cell growth. The research aims to uncover fundamental insights into the molecular mechanisms governing metabolic pathways that enable cellular growth and proliferation, with a focus...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $400,530 to the University of Virginia to develop next-generation "designer nanodiscs" to probe and reprogram membrane biology. The goal is to advance the understanding of how cell membranes regulate the structure, function, and dynamics of proteins involved in key cellular processes like membrane fusion, exosome...
This Project Grant award, valued at $1,380,568.00 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program, supports an interdisciplinary research initiative led by the University of Chicago. The project aims to develop a multiscale, predictive understanding of how cells adapt to changes in their environment, with potential applications in innovative therapeutic interventions for diseases. The research is...
The University of Michigan was awarded a $2.764 million Project Grant from the Department of Health and Human Services Assistant Secretary for Financial Resources under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on the in-situ architecture of membrane contact sites mediating organelle fission. The university will use novel microscopy techniques to visualize and determine the three-dimensional structure of endoplasmic reticulum-mitochondria-lysosome...
This federal Project Grant award, with the ID R35GM154945, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The primary objective of this $389,995 award, granted on September 15, 2024, is to establish an innovative chemical proteomic platform for mapping extracellular proteinaceous cysteines across various biological scenarios, including T cell activation, GGT5 genetic knockout, and chemical...
This $383,799 National Science Foundation project grant supports collaborative research to map protein-membrane interactions across molecular to cellular scales. Funded under the Biological Sciences program (CFDA 47.074), the research aims to better understand how integral membrane proteins and surrounding phospholipid membranes work together to enable cellular processes. The University of Arizona will conduct multiscale modeling from molecular dynamics simulations of single protein-membrane...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $411,250 to The Trustees of Columbia University in the City of New York to conduct research on the interactions between membrane-bound organelles, such as lysosomes, and membrane-less organelles, such as RNA granules. The overarching goal is to understand how these two types of cellular compartments coordinate to maintain RNA...
This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), funds research to understand the mechanisms that regulate subcellular organization and its significance for organelle and cell function. The $852,726 award to The Trustees of the University of Pennsylvania will support the development and application of quantitative, multiplexed super-resolution microscopy techniques...