This Project Grant award of $769,644 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to functionally characterize the lysosome membrane and its protein quality control system. The primary objectives are to: 1) identify substrates of lysosomal E3 ligases in humans, 2) investigate the assembly of the ESCRT machinery to the lysosome membrane for internalizing ubiquitinated cargoes, and 3) determine the...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training federal grant program (CFDA 93.859), is funding research by The Ohio State University to investigate lysosomal membrane dynamics under stress conditions. The $393,750 award, which runs from February 1, 2025 to January 31, 2030, aims to provide a better mechanistic understanding of lysosomal quality control and potential therapeutic applications. Key...
This federal Project Grant award, with ID R35GM154651, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The $381,250 award, effective September 1, 2024 through August 31, 2029, will support research at the University of New Mexico Health Sciences Center (UNM HSC) to investigate the cellular mechanisms underlying the response to lysosomal damage. The research aims to establish the function of...
This $380,540 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to decipher new principles of rapid proteostatic control and develop spatiotemporal lysosomal tools. The key research activities include: 1) defining novel protein substrates and motifs required for lysosomal delivery, 2) determining the functional impact of methyl-driven lysosomal proteolysis on...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $1,102,648 to The Trustees of Columbia University in the City of New York, doing business as Columbia University, to conduct research on how the dynamic molecular interactions of RNA-binding proteins (RBPs) drive post-transcriptional gene expression changes during embryonic stem cell differentiation. The research aims to globally map...
This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), funds research to understand the mechanisms that regulate subcellular organization and its significance for organelle and cell function. The $852,726 award to The Trustees of the University of Pennsylvania will support the development and application of quantitative, multiplexed super-resolution microscopy techniques...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is providing $414,000.00 to Lewis & Clark College from August 1, 2024 to July 31, 2027 to investigate the role of lipid metabolism in the biogenesis of lysosome-related organelles (LROs). The research aims to gain a better understanding of the processes controlling LRO morphology by studying the ACDH-11 protein and its...
The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant totaling $1,385,226 to The Leland Stanford Junior University (Stanford University) under the Biomedical Research and Research Training program (CFDA 93.859). The grant, spanning from September 1, 2023 to August 31, 2026, will support research to map and therapeutically hijack the trafficking of extracellular proteins to the lysosome, a key cellular process involved in regulating cell surface protein function,...
This Project Grant award of $534,160 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports advanced research on the molecular mechanisms underlying intracellular ion transport and genome maintenance. The award to the Sloan-Kettering Institute for Cancer Research in New York will fund a 5-year research program focused on four key areas: Elucidating the mechanisms by which ion transport proteins, such as TMEM175,...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $678,000.00 to Rockefeller University to conduct research on the mechanisms of eukaryotic ribosome assembly. The project aims to develop a detailed understanding of the co-transcriptional assembly and maturation of ribosomal subunits in the nucleolus, a crucial but poorly understood early stage of eukaryotic ribosome biogenesis. The...