Project Grant K99HG013676

Award Date 8/29/24
Completion Date 8/31/26
Dollars Obligated $120K
Federal Grant Program
93.172
Assistance Type
Project Grant
Place of Performance
Michigan, USA
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This Project Grant award, valued at $491,366, was issued by the National Human Genome Research Institute (NHGRI) under the Human Genome Research federal grant program (CFDA 93.172). The award is focused on developing new algorithms to robustly map disease-associated genetic variants to critical target genes, particularly in underrepresented populations. Key objectives include: Improving the ability to identify disease-critical genes in non-European populations where data is limited. Developing...
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The National Human Genome Research Institute (NHGRI) awarded a $119,611 Project Grant under the Human Genome Research program (CFDA 93.172) to the Regents of the University of Michigan. The award period runs from August 29, 2024 to August 31, 2026.

The grant will fund research to uncover regulatory networks controlled by transcription factors associated with monogenic diseases and decipher their involvement in driving complex disease phenotypes. The project aims to use advanced genomic profiling, machine learning, and human genetics data to construct comprehensive regulatory maps linking coding variants in transcription factors and noncoding variants in their cognate motifs. This work will reveal fundamental gene regulatory networks underlying phenotypes shared by common polygenic and rare monogenic diseases, providing insights into the mechanisms by which disease-associated genetic variation exerts its influence. The grant supports the research objectives through a comprehensive training plan and mentorship from subject matter experts in functional genomics, machine learning, and human genetics.

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