Project Grant R01CA300848

Award Date 9/1/24
Completion Date 8/31/29
Dollars Obligated $588K
Funding Federal Agency
Office of the Director
Awarding Federal Agency
National Cancer Institute
Federal Grant Program
93.310
Assistance Type
Project Grant
Place of Performance
Cambridge, MA 02139, USA
Similar Awards
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $222,708 to the Massachusetts Institute of Technology (MIT) to conduct research on the mechanisms of long-range enhancer activity and transcriptional regulation. The key objectives of the project are to: 1) Use super-resolution live-cell imaging to visualize enhancer-promoter interactions and transcription dynamics for the...
This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) supports research to visualize the mechanisms at the intersection of chromatin, transcription, and epigenetics. The $1,525,500 award to Harvard Medical School aims to develop a combinatorial biochemical and structural approach called "Visual Biochemistry" that uses a fully reconstituted chromatin transcription system and time-resolved single-particle...
This Project Grant award of $1,215,158 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to deconvolve the language of protein binding. The project aims to identify the rules and mechanisms that govern the binding of proteins to the genome, with a focus on understanding transcription factor sequence specificity. Key activities include: Applying high-throughput biochemical genomic assays (e.g.,...
This $573,937 five-year Project Grant was awarded on February 1, 2024 by the National Science Foundation's (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074). The grant will fund research at the Massachusetts Institute of Technology (MIT) to understand how changes in DNA structure impact the behavior of synthetic gene circuits and gene expression more broadly. The project aims to develop a better understanding of supercoiling-mediated...
The National Science Foundation awarded a $760,000 project grant to the Massachusetts Institute of Technology from February 1, 2021 through January 31, 2024. The grant is part of NSF's Biological Sciences program (CFDA 47.074) to promote advancement in the biological sciences. Under the award, MIT researchers will investigate protein regulators of three-dimensional genome architecture, dynamics, mechanism and function. Specifically, the grant will fund research into how proteins control the...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $2,720,800.00 in funding to Brigham & Women's Hospital Inc. over a period of 5 years, from July 5, 2024 to May 31, 2029. The award supports research focused on understanding the epigenetic regulation of transcriptional programming, with a particular emphasis on investigating the dynamic competition between Polycomb (PcG) and...
This $292,727 Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) supports a research project by The Broad Institute, Inc. to discover novel regulators of 3D genome organization. The project aims to leverage large-scale genomic datasets to predict and experimentally validate new trans-acting factors that regulate chromatin interactions and genome architecture. By applying deep neural network models to in silico genetic...
This federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) totaling $541,574 will support research to determine whether transcription factor (TF) binding affects the accumulation of DNA damage and mutations in the human genome. The project aims to develop innovative in vitro techniques and quantitative models to assess the ability of TFs to enhance DNA lesion formation and compete with repair proteins. Successful completion of this...
This federal Project Grant award of $651,596 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research by the Cold Spring Harbor Laboratory (CSHL) to study the molecular mechanisms that coordinate gene expression, cell fate determination, and tissue growth during development. The key research objectives are to: 1) Determine the molecular structures and dynamics of three transcriptional complexes that regulate...
This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...

This $588,426 Project Grant award, provided by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), aims to investigate how transcription factors efficiently locate and bind to specific DNA binding sites within the crowded nucleus of living cells. The project will employ advanced microscopy techniques to precisely track the 3D diffusion, DNA interactions, and target site discrimination of transcription factors involved in pluripotency, genome structure, and oncogenic fusion proteins. The research will reveal fundamental insights into transcription factor target search mechanisms, with potential applications in synthetic biology and cancer biology. This transformative approach represents a substantial advancement over traditional methods, enabling unprecedented spatiotemporal resolution of transcription factor search dynamics in live human and mouse cells. The project will be conducted by the Massachusetts Institute of Technology (MIT) from September 2024 through August 2029.

Generated 5/13/25, 4:49 AM