Project Grant R35GM154834
Award Date
9/1/24
Completion Date
7/31/29
Dollars Obligated
$780K
Federal Agency
National Institute of General Medical Sciences
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Portland, OR 97239, USA
Similar Awards
The National Institute of General Medical Sciences (NIGMS) awarded a $274,597 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Yale University. The 5-year grant, effective August 1, 2025, supports research on proteomic and phosphoproteomic remodeling under genomic imbalance, or aneuploidy. The project aims to study the mechanisms of protein regulation and signaling pathways in aneuploid cells, with a focus on distinguishing the effects of chromosome gain...
The National Institute of General Medical Sciences (NIGMS) awarded a $528,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the Sloan-Kettering Institute for Cancer Research located in New York, NY. The purpose of this 4-year grant, with a period of performance from September 30, 2024 to July 31, 2028, is to develop novel approaches to map the folding and protein occupancy of entire chromosomes with single-nucleosome resolution and single-molecule precision. The...
The National Institute of General Medical Sciences (NIGMS) awarded a $470,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The Institute For Cancer Research, a non-profit subsidiary of Temple University, for a 5-year research project starting on September 17, 2024. The goal of the project is to characterize the molecular-level interactions and coordination events coupling the repair of oxidative DNA damage and gene enhancement at G-quadruplex promoter regions in...
The Department of Health and Human Services' National Institute of General Medical Sciences awarded Oregon Health & Science University a $2,680,200 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) for the period September 1, 2022 through August 31, 2025. The grant will support research to elucidate signaling pathways of the P2X7 purinergic receptor and develop novel small molecule and aptamer ligand therapies. Specifically, the recipient will utilize...
The National Institute of General Medical Sciences (NIGMS) awarded a $445,000 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) federal grant program to the Beckman Research Institute of the City of Hope. The grant, awarded on February 1, 2025, will fund research over a 5-year period until January 31, 2030. The key objectives of the project are to: Dissect the structural basis of allosteric modulation by the third intracellular loop (ICL3) of G protein-coupled...
This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...
The National Institute of General Medical Sciences (NIGMS) awarded a $675,609 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) federal grant program to Ometa Labs LLC, a minority-owned small business based in Carlsbad, CA. The grant supports the development of a bioinformatics platform for large-scale untargeted metabolomics analysis. The project will run from August 1, 2025 to July 31, 2027, with the goal of advancing fundamental scientific understanding,...
The National Institute of General Medical Sciences (NIGMS) awarded a $298,530 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Epigenter, LLC in Providence, RI. The goal of this 1-year award, effective July 1, 2025, is to develop and characterize "self-delivering" epigenetic editor proteins that can modulate gene expression by targeted DNA demethylation, without requiring genetic transduction. The project will compare two different protein...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,335,099 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) federal grant program to the University of Chicago. The 5-year award, effective September 2, 2024, will support research to identify the genetic instructions and processes that regulate long-distance interactions between enhancers and promoters, which are critical for gene expression control and have implications for human health. The...
The National Institute of General Medical Sciences (NIGMS) awarded a $242,964 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Oregon. The award will support 2 years of fellowship training and research to understand the mechanisms of cell state transitions underlying organ size control during zebrafish fin regeneration. The research will leverage computational and quantitative imaging approaches to identify fibroblast-lineage cell...