This $588,426 Project Grant award, provided by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), aims to investigate how transcription factors efficiently locate and bind to specific DNA binding sites within the crowded nucleus of living cells. The project will employ advanced microscopy techniques to precisely track the 3D diffusion, DNA interactions, and target site discrimination of transcription factors involved in...
This federal Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) provides $1,031,008 to St. Jude Children's Research Hospital Inc. to conduct research on dissecting the contributions of phase separation to yeast transcription. The primary objectives are to: 1) examine how transcription factors, coactivators, and DNA phase separate together and how multivalent interactions and solubility contribute to their...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 - Biomedical Research and Research Training, aims to advance the understanding of how homeodomain (HD) transcription factors (TFs) regulate gene expression and impact human health. The $510,390 award to the Children's Hospital Medical Center in Cincinnati, Ohio will fund a 5-year research program to investigate the mechanisms underlying HD TF DNA binding specificity, the functional impact...
The U.S. National Institute of General Medical Sciences (NIGMS) awarded a $667,480 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to St. Jude Children's Research Hospital Inc. on May 1, 2025. The grant supports a 5-year research project focused on studying the structural and functional dynamics of chromatin, which plays a critical role in cellular processes like gene expression, DNA replication, and cell differentiation. The research aims to advance the understanding...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $222,708.00 to the Massachusetts Institute of Technology (MIT) to conduct research on the mechanistic basis of individual and clustered enhancers in human cells. The goal is to gain a comprehensive and quantitative understanding of how dynamic enhancer-promoter interactions regulate transcription in different cell...
This Project Grant award for $125,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program, supports research to investigate the role of protein N-myristoylation in the DNA damage response (DDR) and its impact on genomic stability. The key objectives of this award are to: 1) Assess the association between N-myristoylation, modulated by NMT1 and NMT2, and DDR pathways, including the impact on DNA...
The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $780,000 Project Grant to Oregon Health & Science University (OHSU) effective September 1, 2024 through July 31, 2029. The grant supports the development of innovative proteomic tools to study transcription factor-coregulator interactions and their role in gene regulation, cellular differentiation, and disease progression. Key objectives include...
The National Institute of General Medical Sciences (NIGMS) awarded a $250,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Regents of the University of Minnesota, Office of Sponsored Projects Administration. This funding will support research to define the mechanisms governing MYC protein stability and its modulation by the Aurora Kinase A enzyme. The research aims to structurally characterize the MYC-Aurora Kinase A complex using techniques like...
This Project Grant award, with a total funding amount of $508,750.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training federal grant program (CFDA 93.859). The award aims to uncover the epigenetic mechanisms that underlie stem cell fates during embryogenesis, with a focus on understanding how histone H3 lysine 27 (H3K27) modifiers respond to intrinsic and external cues to regulate gene expression and control cell...
This federal Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower) provides $342,102 to The Johns Hopkins University to conduct research on the role of the chromatin regulator HMGA1 in KMT2A-rearranged acute myeloid leukemia (AML). The research aims to elucidate the mechanisms by which HMGA1 drives leukemogenesis and therapy resistance in this aggressive form of AML, which is resistant to current treatments. The project will involve defining the role of...