This $435,126 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the University of Chicago's research project titled "Connecting Circadian Clock Dynamics to Metabolism and Fitness." The project aims to understand the biophysical basis of circadian rhythms and their connection to metabolism, health, and fitness using a bacterial model system. Key objectives include creating new technologies to enable novel assays, extending protein reconstitution systems to mimic cellular processes, and using deep scanning mutagenesis to map the molecular determinants and evolutionary pressures on the circadian clock. This 5-year project, running from January 2025 to December 2029, leverages the University of Chicago's expertise in areas such as live cell microscopy, protein biochemistry, and high-throughput sequencing to advance the fundamental understanding of how circadian rhythms interact with cellular metabolism and fitness.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $435.1k | 1/17/25 |