Project Grant R01GM157609
Award Date
9/13/24
Completion Date
7/31/27
Dollars Obligated
$415K
Funding Federal Agency
Assistant Secretary for Financial Resources
Awarding Federal Agency
National Institute of General Medical Sciences
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Missouri, USA
Similar Awards
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), aims to unravel the molecular interconnections between circadian rhythms and lipid metabolism. The $574,021 award, effective from February 1, 2025 to January 31, 2030, will be provided to the University of Missouri System to address three key knowledge gaps: 1) how phosphatidic acid (PA) mediates nuclear processes, 2) how...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $435,126 to the University of Chicago to conduct research on the biophysical basis of circadian rhythms and their connection to metabolism and fitness. The research aims to understand how an appropriately timed metabolic switch allows cells to tolerate cycling environments. Key activities include developing new technologies...
This $651,596 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training Program supports research at Cold Spring Harbor Laboratory (CSHL) to investigate the molecular underpinnings of a developmental clock that coordinates cell fate specification in C. elegans. The research aims to determine the structures of three complexes that assemble and disassemble to regulate dynamic microRNA transcriptional patterns,...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $361,454 in funding to the University of Massachusetts Boston to investigate the mechanisms underlying nutritional compensation in the circadian clock. The key objectives of this 5-year research project are to: 1) define the cellular effectors and metabolic variables that control circadian oscillations in fungi and test for...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $542,354 Project Grant (CFDA 93.853) to The Washington University to investigate how neural connectivity in the suprachiasmatic nucleus (SCN) adapts to changes in photoperiod (day length). The project aims to map changes in cell-cell connectivity in the SCN as it adjusts to long and short day conditions, using in vivo and in vitro techniques combined with computational modeling. A sub-award of $250,038 was provided...
This federal Project Grant award of $440,454 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) will support a research project focused on epithelial cell mechanobiology in mechanically heterogeneous microenvironments. The primary objectives are to study how epithelial cells sense and respond to extracellular wounds, whether epithelial migration can occur with lower forces by modifying extracellular matrix...
This National Science Foundation (NSF) Project Grant, under the Biological Sciences program (CFDA 47.074), provides $240,000 in funding from February 1, 2024 to January 31, 2027 to support a postdoctoral research fellowship focused on investigating a novel circadian time-keeping mechanism revealed by environmental manipulation. The research plan aims to identify the location in the brain and the mechanism of a non-canonical clock that can rescue daily rhythms in mice with disrupted central clock...
This $584,420 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports spatiotemporal mapping and engineering research on the "dark proteome" - intrinsically disordered proteins and their functions. The award, which runs from April 1, 2025 to January 31, 2030, enables researchers at the Albert Einstein College of Medicine to investigate the role of protein disorder in nuclear...
The University of California, San Francisco (UCSF) has been awarded a $1,453,500 Project Grant under the National Institutes of Health (NIH) Trans-NIH Research Support (CFDA 93.310) program. The grant, awarded on September 20, 2023 with a completion date of August 31, 2026, will support UCSF's research to decipher the fundamental principles of autonomous cellular clocks and uncover their role in regulating critical cellular processes like metabolism, organelle biogenesis, and mitotic fidelity....
This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...