This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will provide $451,250 to Childrens Hospital Medical Center in Cincinnati, Ohio over a 5-year period from May 2025 to March 2030. The grant will support research to investigate the mechanisms that harmonize circadian clock gene expression in the brain's oscillators with rhythmic signals from the central pacemaker in the...
This $574,021 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to investigate the molecular mechanisms connecting circadian rhythms and lipid metabolism. The 5-year project led by the University of Missouri System will use a range of techniques, including lipid imaging, subcellular lipidomics, and genetic editing, to address three key knowledge gaps: 1) how the lipid messenger phosphatidic...
This $435,126 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the University of Chicago's research project titled "Connecting Circadian Clock Dynamics to Metabolism and Fitness." The project aims to understand the biophysical basis of circadian rhythms and their connection to metabolism, health, and fitness using a bacterial model system. Key objectives include...
The National Institute of General Medical Sciences (NIGMS) awarded a $382,755 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to the Regents of the University of California at Riverside. The project, titled "Mechanisms Underlying Circadian Gating of Stress Responses," aims to investigate how the circadian clock in plants regulates gene expression and physiological responses to environmental stresses over the course of a day. The research...
This $438,915 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support research at Florida State University (FSU) to advance the understanding of the genetic basis of circadian rhythms and sleep disorders. The key objectives of the 5-year project are: 1) Identifying pathogenic mutations in human clock genes that can cause sleep disorders, 2) Elucidating the molecular mechanisms linking the...
This federal Project Grant award of $1,457,999.00 from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) supports research on how the circadian clock coordinates animal and microbial metabolism. The funded project aims to investigate the mechanisms by which circadian clocks and feeding rhythms promote oscillations in microbiome composition and function, and how these microbial metabolic cycles impact host physiology. The...
This federal Project Grant award, with an ID of R35GM155111, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The $1,150,390 award will fund a 5-year research project to study sex differences in circadian output signaling from the brain clock to peripheral metabolic tissues in the Drosophila melanogaster genetic model. The key objectives are to: 1) Identify sex-specific circuitry and signaling...
This National Science Foundation (NSF) Project Grant, under the Biological Sciences program (CFDA 47.074), provides $240,000 in funding from February 1, 2024 to January 31, 2027 to support a postdoctoral research fellowship focused on investigating a novel circadian time-keeping mechanism revealed by environmental manipulation. The research plan aims to identify the location in the brain and the mechanism of a non-canonical clock that can rescue daily rhythms in mice with disrupted central clock...
This Project Grant award, totaling $216,736.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research project aims to identify the mechanisms by which the host circadian clock and gut microbiome regulate mucus production in the large intestine to protect against infectious and chemical colitis. Key objectives include determining the specific microbiota...
The National Institute of General Medical Sciences (NIGMS) awarded a $406,250 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Trustees of the University of Pennsylvania, with a performance period from June 1, 2025 to April 30, 2030. The grant supports two key research directions: 1) investigating the mechanisms of transcription factor functional divergence and its role in driving cellular and organismal complexity, and 2) identifying the genetic...