Project Grant R35GM156357

Award Date 6/1/25
Completion Date 5/31/30
Dollars Obligated $439K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Florida, USA
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This $361,454 federal Project Grant award was issued by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The grant supports research to elucidate the molecular mechanisms underlying circadian clock period compensation in fungi and mammals. The key objectives are to: 1) Define cellular effectors and metabolic variables controlling circadian oscillations in fungi, and test for conservation in human cells, and 2)...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $451,250 to support research investigating the molecular mechanisms that coordinate circadian clock gene expression in the brain's central pacemaker and peripheral oscillators. The 5-year project aims to elucidate how internal and external signals, particularly light exposure, are integrated to regulate circadian...
This Project Grant award for $651,596, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research conducted by the Cold Spring Harbor Laboratory (CSHL) to study molecular timekeeping and temporal cell fate specification in the model organism C. elegans. The research aims to understand the molecular underpinnings of a "molecular clock" that coordinates cell fate specification and...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research by the University of Chicago to investigate the connection between circadian rhythms, metabolism, and fitness. The $435,126 award, which runs from January 2025 to December 2029, leverages a bacterial model system to quantify the relationship between the circadian clock and external environmental factors required for...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) is focused on unraveling the molecular connections between circadian rhythms and lipid metabolism. The $574,021 award, made on February 1, 2025, will support research at the University of Missouri System to address three key knowledge gaps: 1) how the lipid molecule phosphatidic acid (PA) mediates nuclear processes, 2) how PA and lipid...
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This $438,915 five-year Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research at Florida State University (FSU) to advance the understanding of circadian rhythms and sleep disorders. The key products and services to be delivered under this grant include:

  1. Identification and characterization of genetic polymorphisms and mutations in human clock genes that can cause altered sleep patterns and sleep disorders. FSU has developed a cell-based platform to efficiently screen and analyze dozens of natural and hypothetical clock gene mutations.

  2. Investigation of the molecular links between the circadian clock and sleep homeostasis mechanisms, including analyzing differences in circadian clock behavior between genetically modified mouse models to uncover how the clock regulates temporal sleep pressure.

  3. Discovery of novel clock genes through a high-throughput CRISPR screening approach using a human cell line engineered to report on endogenous clock gene expression.

The award aims to provide important insights for treating a variety of diseases in which sleep disorders are major causes, symptoms, or comorbidities. The grant period runs from June 1, 2025 to May 31, 2030.

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