Project Grant R35GM155443
Award Date
7/4/24
Completion Date
5/31/29
Dollars Obligated
$1.1M
Federal Agency
National Institute of General Medical Sciences
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Urbana, IL 61801, USA
Similar Awards
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will fund research to elucidate the structure and interactions of a model bacterial fibrillar adhesin, the Pseudomonas aeruginosa biofilm matrix protein CdrA. The award, totaling $1,166,250, will enable the principal investigator at the Washington University to dedicate greater time and resources towards addressing the limited structural and...
This $361,297 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to characterize the regulation of cell envelope biosynthesis in the opportunistic pathogen Pseudomonas aeruginosa. The key research goals are to: (I) dissect the molecular basis of lipopolysaccharide (LPS) and peptidoglycan (PG) coordination and the consequences of uncoupling these pathways, (II) characterize two novel...
The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), awarded a $761,271 Project Grant to the University of Illinois to study the physiology of oxidative stress in bacteria. The award, effective July 1, 2025, will support research to detail the threats that oxygen poses, the defenses that organisms have evolved, and the situations in which oxidative stress impacts microbial fate. Key objectives include identifying...
The University of Illinois was awarded a $350,487 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant, awarded on September 15, 2024, supports a research project entitled "Uncovering Novel Heme Chemistry in Microbial Systems." The project aims to expand the understanding of how divergent bacterial diheme proteins stabilize and utilize high-valent bis-FeIV states for...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $1,112,547 in funding to Texas A&M University over a 5-year period from July 1, 2024 to June 30, 2029. The award supports research to understand the molecular-level function and assembly of type IV pili (TFP), which are bacterial nanomachines involved in various virulence factors in the opportunistic pathogen...
This federal Project Grant award, totaling $1,605,000.00 and administered by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the molecular mechanisms by which cell wall-anchored proteins in Staphylococcus bacteria promote biofilm formation and virulence. The research will focus on several key proteins, including AAP, SASG, SASC, SBP, and SASX, and aims to provide a structural...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $779,915.00 in funding to the Scripps Research Institute to investigate the chromatin remodeling functions of polyphosphate condensates in the opportunistic pathogen Pseudomonas aeruginosa. The research aims to define the relationship between polyphosphate and the DNA-binding protein AlgP as regulators of gene expression and virulence, evaluate...
This $144,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to identify the binding sites and regulated genes of the MerR-family of transcription factors in the opportunistic pathogen Pseudomonas aeruginosa. The research team at Kennesaw State University will use an iterative selection method called Restriction Endonuclease Protection Selection and Amplification...
This federal Project Grant award, valued at $637,275.00 and awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to uncover the mechanisms by which Gram-negative bacterial pathogens develop rapid tolerance to chemical stressors, such as antibiotics. The research aims to elucidate how these bacteria can inhibit the functioning of existing porin proteins in their outer membranes...
The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Chicago to conduct in-situ investigations of bacterial secretion systems using cryo-electron tomography. The $410,000 grant, awarded on July 1, 2025, will support research aimed at elucidating the assembly, disassembly, and function of two key bacterial secretion systems: the flagellar motor (a type III secretion system) and the type IV...