Project Grant R35GM155188

Award Date 7/15/24
Completion Date 5/31/29
Dollars Obligated $389K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
University City, MO 63130, USA
Similar Awards
This $382,600 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund research at Northeastern University to elucidate the fundamental mechanisms of bacterial surface glycan dynamics. The key objectives include: Constructing a searchable in silico library of bacterial surface glycans tailored for computational docking studies, focusing initially on amino sugars and essential...
This $802,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program will fund research to understand the molecular mechanisms by which cell wall-anchored proteins on the surface of Staphylococcus bacteria promote biofilm formation and virulence. The 5-year project, awarded to Childrens Hospital Medical Center in Cincinnati, Ohio, will focus on investigating specific Staphylococcus surface proteins involved in...
The National Institute of General Medical Sciences (NIGMS) awarded a $361,297 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Georgia Research Foundation to characterize the regulation of cell envelope biosynthesis in the bacterial pathogen Pseudomonas aeruginosa. The research aims to: Dissect the molecular basis and physiological consequences of coordinating lipopolysaccharide (LPS) and peptidoglycan (PG) biosynthesis, which are essential cell...
This five-year, $370,086 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) aims to improve understanding of type IV pili (TFP) in the pathogen Pseudomonas aeruginosa using single-molecule microscopy techniques. The research program will utilize super-resolution microscopy and single-molecule FRET to investigate how TFP complexes are assembled, how their molecular components dynamically interact...
The National Institute of General Medical Sciences (NIGMS) awarded a $372,497 five-year Project Grant (CFDA 93.859 Biomedical Research and Research Training) to the University of Illinois to investigate how host-relevant fluid flow and hydrogen peroxide stress impact the pathogenic bacterium Pseudomonas aeruginosa. The research will use microfluidic technology to model natural conditions and study three key areas: 1) the impact of spatial hydrogen peroxide gradients on bacterial communities,...
The National Institute of General Medical Sciences (NIGMS) awarded a $440,454 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The Washington University in St. Louis to study epithelial cell mechanobiology in heterogeneous microenvironments. The 5-year project, running from January 14, 2025 to November 30, 2029, will investigate how epithelial cells sense, respond to, and retain mechanical memory of their extracellular matrix environment. Key focus areas include...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $402,500 to New York University (NYU) to develop a novel approach that combines modular fluorophores and correlative super-resolution microscopy to investigate the structure, dynamics, and interactome of biomolecular condensates in bacteria. The goal is to apply this opto-proteomic toolbox to understand the role of...
This $350,487 federal Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is funding research to uncover novel heme chemistry in microbial systems. The research aims to better understand how divergent bacterial diheme proteins stabilize high-valent bis-FeIV states and leverage these intermediates for site-specific substrate oxidation. The research will leverage genomic data to expand the...
This $396,525 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research program) supports research to better understand the relationship between bacterial metal content and cellular metabolism at the single-cell level. The prime awardee, Washington University, will develop novel techniques to simultaneously measure metal composition and gene expression patterns in individual bacterial cells in order to...
This $441,250 five-year Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training) will support research by the University of Washington aimed at understanding the mechanisms underlying bacterial chromosome organization. The key objectives are to: 1) elucidate the function of the regulator protein GAPR as a model for how bacteria and bacteriophages control DNA supercoiling to enable cell proliferation, 2) identify...

The National Institute of General Medical Sciences (NIGMS) awarded a $388,750 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The Washington University to conduct structural and functional investigations of bacterial fibrillar adhesins. This multi-year research project, with a performance period from July 2024 to May 2029, aims to elucidate the structure and interactions of a model fibrillar adhesin from Pseudomonas aeruginosa. The research seeks to address a significant knowledge gap in understanding this widely abundant bacterial adhesion mechanism, which is critical for infection and biofilm formation. The Project Grant will enable the principal investigator to dedicate resources and train a diverse team of scientists at the intersection of molecular biophysics and microbiology to study these high molecular weight, repetitive proteins.

Generated 4/1/25, 4:50 AM