This $569,210 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to structurally and functionally characterize three key proteins responsible for antimicrobial peptide/colistin resistance in Gram-negative bacteria, including high-threat pathogens like carbapenem-resistant Acinetobacter baumannii and Enterobacteriaceae. The research aims to develop...
This $462,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to decipher the genetic regulation of bacterial heterogeneity in response to antibiotic stress using single-cell transcriptomics. The research, conducted at St. Jude Children's Research Hospital, will employ bacterial single-cell RNA sequencing technology to map the genetic factors driving bacterial heterogeneity and elucidate...
This federal Project Grant award, totaling $195,625.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to structurally and functionally characterize phosphoethanolamine (PEtN) transferases, which are enzymes responsible for conferring resistance to cationic antimicrobial peptides and polymyxin antibiotics in certain Gram-negative bacteria. The research aims...
This federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to identify mechanisms of resistance to pathogen-specific antibacterial antisense compounds known as peptide-phosphorodiamidate morpholino oligomers (PPMOs) and develop strategies to overcome them. The $254,478 award to the University of Texas Southwestern Medical Center will fund a 2-year project...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $1,379,734 to the University of Texas at Austin to conduct research on microcin antibacterial proteins. The goal is to better understand how these small proteins can overcome the outer membrane permeability barrier of Gram-negative bacteria, a major challenge in developing new antibiotics. The research aims to link...
This federal Project Grant award, valued at $294,824, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant aims to understand the impact of glutamine starvation on improving antibiotic efficacy against Mycobacterium tuberculosis (MTB) infection. Specifically, the research will explore how glutamine starvation affects MTB antibiotic tolerance, immune vulnerability, and infection...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $312,000 in funding to the University of Texas Health Science Center at Houston (UTHealth) to conduct research focused on understanding pathogenesis and antibiotic tolerance in the bacterium Staphylococcus aureus. The central aims of this two-year award are to explore the relationship between heterogeneous...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $749,417 to President and Fellows of Harvard College to conduct research focused on developing novel antibiotics to address the challenge of multi-drug resistant bacterial pathogens. The research aims to synthesize and evaluate new antibiotic compounds that target the lipoprotein transport pathway in...
This $2,308,174 federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to develop new antibiotic combinations and dosing strategies to combat carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae. The award, which runs from August 8, 2024 to May 31, 2029, involves three projects and three cores conducted by the University of Florida, the...
This federal Project Grant award of $784,059.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the role of the protein calprotectin in modulating antibiotic efficacy during bacterial infections. The key objectives of the research are to: 1) Determine the impact of calprotectin's ability to hydrolyze and inactivate certain beta-lactam antibiotics, such as...