This Project Grant award of $453,621.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to understand how changes in the lipopolysaccharide (LPS) composition of the bacterial pathogen Pseudomonas aeruginosa (PA) influence aggregate formation and social behaviors in chronic cystic fibrosis lung infections. The key products and services to be delivered include: (1) determining the frequency of PA...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $868,776 to The Children's Hospital Corporation (doing business as Boston Children's Hospital) to characterize a novel post-transcriptional regulator in the opportunistic pathogen Pseudomonas aeruginosa. The research aims to identify the direct regulatory targets of the PHAF protein under various growth...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $783,557 to the University of Washington to conduct research on the molecular determinants and functions of bacterial polysaccharide cellular localization. The research aims to examine how the Psl and Pel exopolysaccharides produced by Pseudomonas aeruginosa exist in different isoforms and how their cellular...
This federal Project Grant award, totaling $195,625.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to structurally and functionally characterize phosphoethanolamine (PEtN) transferases, which are enzymes responsible for conferring resistance to cationic antimicrobial peptides and polymyxin antibiotics in certain Gram-negative bacteria. The research aims...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $205,000.00 to The Trustees of Princeton University to examine the influence of chromosome copy number on Pseudomonas aeruginosa persister cells that tolerate fluoroquinolone antibiotics. The key research objectives are to: 1) Measure chromosome copy number in individual P. aeruginosa cells and correlate this...
This $728,497 project grant from the National Institutes of Health's National Institute of Allergy and Infectious Diseases will fund research at Idaho State University from August 2022 through July 2025 on the role of metal ion homeostasis in regulating bacterial capsule production. The goal is to identify the molecular mechanisms by which cellular ratios of manganese, zinc, and calcium influence capsule polysaccharide production in Streptococcus pneumoniae, a gram-positive pathogen. Researchers...
This $728,244 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund research to investigate the mechanisms of virulence factors and injectisome assembly in bacterial pathogens like Salmonella, Shigella, Vibrio, Pseudomonas, Yersinia, and Chlamydia. The research aims to provide fundamental knowledge about injectisome function and gene regulatory systems, which is crucial for...
This $794,849 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to investigate mechanisms driving Pseudomonas aeruginosa resistance and cross-protection against the antibiotic cefiderocol. The award to Cedars-Sinai Medical Center will fund a 5-year research project with the central hypothesis that siderophores and fitness costs linked to siderophore production can...
This Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to optimize the regimen structure and characterize the pharmacokinetics and pharmacodynamics of a multi-phage cocktail therapy for treating extensively drug-resistant Pseudomonas aeruginosa infections. The $714,053 award, with a period of performance from August 2024 to July 2029, will fund the development of a...
This Project Grant award of $453,900.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 - Allergy and Infectious Diseases Research program supports research to develop a genome editing platform based on phage recombinases that can operate across a broad range of bacterial species, including clinically relevant pathogens. The award to the University of Rochester aims to transform genetic manipulation capabilities for bacteria by leveraging phage proteins...