Project Grant R35GM157116

Award Date 7/1/25
Completion Date 4/30/30
Dollars Obligated $410K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Illinois, USA
Similar Awards
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), Biomedical Research and Research Training Program (CFDA 93.859), provides $1,683,145.00 to the University of Chicago to investigate the mechanisms governing the self-organization and interactions of diverse actin cytoskeleton networks in cells. The research aims to determine how cells allocate actin monomers between competing actin filament networks to control network size and density, as well as...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), will provide $402,500 to New York University (NYU) to develop a novel approach that combines modular fluorophores and correlative super-resolution microscopy. The goal is to investigate the structure, dynamics, and interactome of bacterial biomolecular condensates and understand their role in various aspects of the...
This $109,255 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA Program 93.859 Biomedical Research and Research Training, supports research to determine how the material state of protein complexes influences mechanisms of protein quality control in bacteria, and to develop systems for spatially regulating bacterial protein condensates. The research aims to advance understanding of the differences between bacterial protein condensates and...
The National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) has awarded a $441,250 Project Grant (R35GM154727) to the University of Washington to investigate regulators of bacterial chromosome organization. The key objectives are to: 1) elucidate the mechanism of the GAPR protein as a model for understanding how bacteria and bacteriophages control positive supercoiling to proliferate, 2) identify additional topoisomerase regulators...
The National Institute of General Medical Sciences (NIGMS) awarded a $357,666 Project Grant (CFDA 93.859 Biomedical Research and Research Training) to the University of Missouri System to study the coordination of complex dynamics by DNA manipulating enzymes. Over the 5-year project period from July 1, 2025 to May 31, 2030, the researchers will use a combination of single-molecule force and fluorescence measurements, as well as computational methods, to investigate the activity and...
The National Institute of General Medical Sciences (NIGMS) awarded a $645,905 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Yale University. The grant supports research to characterize the dynamics of chemotactic signal processing and the role of cell-to-cell variability in chemotactic behavior across bacterial species, including Vibrio cholerae and Pseudomonas aeruginosa. Key objectives include understanding how a common signaling architecture can be...
The National Institute of General Medical Sciences (NIGMS) awarded a $788,940 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Nebraska Medical Center (UNMC) to investigate the function of bacterial cytoskeletal elements in the division and growth of Chlamydia, an obligate intracellular bacterial pathogen. The project aims to 1) understand how the MreB cytoskeletal protein is maintained at the division septum and the role of...
The National Institute of General Medical Sciences (NIGMS) awarded a $2,070,444 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Chicago to characterize the genetic and evolutionary determinants of population variation in transcriptional responses to pathogens. The research program will explore the effects of natural selection and genetic ancestry on gene expression, epigenetic traits, and immune responses to infection across diverse human populations....
The University of Illinois was awarded a $350,487 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant, awarded on September 15, 2024, supports a research project entitled "Uncovering Novel Heme Chemistry in Microbial Systems." The project aims to expand the understanding of how divergent bacterial diheme proteins stabilize and utilize high-valent bis-FeIV states for...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $556,510 to conduct research on the molecular mechanisms and evolutionary aspects of the rhoptry secretion system in unicellular eukaryotes within the Alveolata superphylum, including apicomplexan parasites and non-pathogenic ciliates. The research aims to understand the conserved architecture of these secretion...

The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Chicago to conduct in-situ investigations of bacterial secretion systems using cryo-electron tomography. The $410,000 grant, awarded on July 1, 2025, will support research aimed at elucidating the assembly, disassembly, and function of two key bacterial secretion systems: the flagellar motor (a type III secretion system) and the type IV secretion system. Using cutting-edge microscopy techniques, the researchers will directly visualize these macromolecular complexes within intact bacterial cells to gain a deeper understanding of how bacteria assemble and disassemble these vital nanomachines in response to environmental conditions. The findings from this 5-year project are expected to advance scientific knowledge about the general mechanisms underlying the assembly and function of macromolecular complexes in bacteria.

Generated 6/24/25, 4:50 AM