The federal Project Grant award R35GM156305, funded by the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859), will support research to examine how key physical cues, including extracellular fluid viscosity, microenvironmental stiffness, and cellular confinement, regulate cell responses such as migration and invasion. The $479,487 award, with a project period from February 1, 2025 to January 31, 2030, will be performed by The...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA Program 93.859 Biomedical Research and Research Training, is funding a research project titled "Investigating the Role of Signaling Feedback in Directed Cell Migration." The $147,656 award, with a project period from December 2024 to September 2027, will support investigations into the mechanisms by which cells regulate signaling pathways to control navigation during cell...
This $300,477 federal Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The award will support a 5-year research project focused on investigating the molecular regulation of cell protrusion function in 3D environments. The research aims to develop computational algorithms based on computational geometry to reconstruct plasma membrane organization from 3D microscopy images and...
The National Institute of General Medical Sciences (NIGMS) awarded a $509,982 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Maryland, College Park to support research on the fundamental mechanisms governing cell-cell communication during animal development. The key objectives are to unravel the precise regulatory mechanisms controlling cytoneme-mediated signaling, which enables polarized exchange of essential signaling proteins like fibroblast...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), supports a multi-scale modeling and experimental investigation into tissue fluidity patterns in the partial epithelial-mesenchymal transition (pEMT) state. The $305,426 award, effective from September 15, 2024 to August 31, 2028, aims to develop mathematical theories, numerical methods, and experimental studies to elucidate how...
This federal Project Grant award of $435,875 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to enhance the understanding of epithelial cell polarization and behaviors in tissue morphogenesis. The key objectives of this 5-year research program are to: 1) investigate the molecular mechanisms of apical intercalation and apical membrane protein sorting in mammary epithelial cells, using...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $389,600.00 in funding to Drexel University to conduct research on the physical mechanisms of 3D cell motility. The research aims to establish how distinct pools of actomyosin contractility are linked to the control of cytoplasmic hydraulic pressure to achieve 3D cell migration, with a focus on understanding how the cell...
This $526,451 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of a novel optical microscopy modality for cell biomechanics research. The primary objectives are to: Implement technical innovations to maximize the throughput of stimulated Brillouin scattering (SBS) microscopy, achieving a 100-fold improvement in acquisition speed compared to current state-of-the-art....
This $393,093 federal Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) will support a research program to uncover the interplay between gene expression, cell morphology, and tissue-level mechanics in embryonic development. The research aims to develop an integrative computational framework to analyze spatio-temporal data on gene expression, cell morphometrics, and tissue mechanics...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $395,387 to support research on the molecular mechanisms driving fast amoeboid cell migration. The award aims to deconstructing this poorly understood, three-dimensional migration mode that is commonly used by invasive cancer cells. Over the next 5 years, the research will focus on understanding the cortical actin architectures,...