This federal Project Grant award of $440,454 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) will support a research project focused on epithelial cell mechanobiology in mechanically heterogeneous microenvironments. The primary objectives are to study how epithelial cells sense and respond to extracellular wounds, whether epithelial migration can occur with lower forces by modifying extracellular matrix...
This Project Grant award, with a total funding amount of $389,211, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The primary goal of the award is to conduct fundamental research on the biophysics and cell biology of meso-scale gap closure, a critical process in wound healing and tissue homeostasis. The research will involve tracking and characterizing cell kinematics, proliferation, force...
This $409,375 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to determine how membrane fluidity regulates embryonic cell migration. The principal investigator at The Johns Hopkins University will use in vivo and ex vivo live cell imaging, optogenetic approaches, and targeted gene manipulation to investigate 1) how membrane fluidity orients cell migration, and 2)...
The National Institute of General Medical Sciences (NIGMS) awarded a $389,600 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to Drexel University. The grant, awarded on February 1, 2025, with a completion date of January 31, 2030, will support research to understand the physical mechanisms governing 3D cell motility through extracellular matrices. The project aims to investigate how cells regulate actomyosin contractility and water influx to power the...
The National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation awarded a $299,990 Project Grant to Worcester Polytechnic Institute to investigate how tissue stiffness and fluid flow coordinate to regulate lymphatic capillary growth and function. This two-year award, issued on February 1, 2022 with a completion date of January 31, 2024, falls under the NSF Directorate for Engineering's CFDA #47.041 Engineering program. The program seeks to improve quality of life...
This Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), is investigating the role of signaling feedback in directed cell migration. The $147,656 award, made on December 21, 2024, supports research to better understand how cells maintain faithful cell migration by regulating key signaling pathways such as PI3K, Ras, and Rac. The experiments aim to determine how negative feedback and...
This Federal Project Grant award from the National Institute of General Medical Sciences (NIGMS, CFDA 93.859 Biomedical Research and Research Training) provides $367,105 to the University of Wisconsin System to support research on extracellular matrix (ECM) remodeling. The project aims to advance methods for visualizing and mechanically characterizing heterogeneous ECM at multiple scales, which is critical for understanding how pathological changes in ECM contribute to disease progression. Key...
The National Institute of General Medical Sciences (NIGMS) awarded a $368,235 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of New Hampshire (UNH) to establish an integrated bioengineering framework for understanding how the synergistic effects of soluble and bound factors in biomaterials influence cell signaling and modulate cell function to promote chronic wound angiogenesis and healing. The project aims to develop an in vitro microfluidic...
This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support a $361,054 research project at Virginia Commonwealth University (VCU) from July 1, 2024 to May 31, 2029. The project aims to investigate how mechanical cues in the cellular microenvironment activate leader cells and drive directional collective cell migration, which is essential for processes like wound healing and cancer...