Project Grant R35GM158230
Award Date
6/1/25
Completion Date
5/31/30
Dollars Obligated
$436K
Federal Agency
National Institute of General Medical Sciences
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Nashville, TN 37203, USA
Similar Awards
The National Institute of General Medical Sciences (NIGMS) awarded a $627,797 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Cornell University. The goal of this 5-year research program is to delineate the molecular mechanisms connecting endocytic and junctional complexes with epithelial pathology in the model organism C. elegans. The research leverages a multidisciplinary approach combining genetic screens, live cell imaging, biochemical assays, and...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $409,375.00 in funding to The Johns Hopkins University to support research on how membrane fluidity regulates embryonic cell migration. The project aims to determine 1) how membrane fluidity orients in vivo cell migration, and 2) how cells regulate local membrane fluidity. The research will utilize in vivo and ex vivo live...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $509,982.00 to the University of Maryland, College Park to conduct research on the fundamental mechanisms governing cell-cell communication that underlie animal development. The primary focus of the research is to unravel the precise regulatory mechanisms controlling the formation and function of signaling filopodia, known...
This federal Project Grant award of $490,841 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate the mechanical coordination and mechano-biochemical feedback mechanisms that regulate epithelial tissue folding during embryogenesis. The primary objectives of the research are to: 1) Investigate the feedback regulation of the actomyosin network during apical constriction of cells, 2)...
This $1,104,819 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports a long-term research project to identify and characterize the "directional cues" that coordinate long-range organization of planar cell polarity (PCP) across tissues. The project, awarded to the Regents of the University of Minnesota, will leverage natural genetic variants in mouse epidermal tissues to interrogate...
This $422,173 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to advance the understanding of cellular signaling networks controlling organ growth and tissue patterning during organism development. The key research directions include: 1) investigating the ERK-mediated downregulation of the transcriptional repressor Capicua and its regulatory network, 2) studying novel...
The National Institute of General Medical Sciences (NIGMS) awarded a $541,967 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Chicago. The grant, valid from January 1, 2025 through December 31, 2029, supports research to expand the understanding of adherent cell mechanics and mechanobiology. Key focus areas include investigating the force-sensitive remodeling of cell-cell adhesions and the role it plays in contact inhibition of...
The National Institute of General Medical Sciences (NIGMS) awarded a $421,600 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the Morgridge Institute for Research, Inc. to investigate the interplay of genetic and environmental factors that influence human cell fitness. The project aims to: 1) understand context-dependent genetic contributions to cell growth, 2) examine physiologic nutrient dependencies, and 3) delineate environmental contributions to T cell fitness....
This federal Project Grant award of $852,726 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop innovative quantitative microscopy tools to study the spatial organization and functional roles of organelles, proteins, and the genome within cells. The 5-year project, awarded to The Trustees of the University of Pennsylvania, will leverage advanced imaging techniques to elucidate how molecular assemblies...
This Project Grant award of $389,600.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research at Drexel University to understand the fundamental principles of directional 3D cell motility and migratory plasticity. The research aims to explore how human cells move through 3D extracellular matrices, focusing on understanding how the cell's intracellular architecture and polarity are reprogrammed to power...