Project Grant R35GM155189
Award Date
9/1/24
Completion Date
6/30/29
Dollars Obligated
$1.2M
Federal Agency
National Institute of General Medical Sciences
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Chicago, IL 60637, USA
Similar Awards
This Project Grant award, valued at $1,380,568.00 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program, supports an interdisciplinary research initiative led by the University of Chicago. The project aims to develop a multiscale, predictive understanding of how cells adapt to changes in their environment, with potential applications in innovative therapeutic interventions for diseases. The research is...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $541,967 to the University of Chicago to investigate the mechanical behaviors of cells and their impact on physiological processes and diseases. The research aims to expand the understanding of adherent cell mechanics and mechanobiology, focusing on the force-sensitive remodeling of cell-cell adhesions and the role of LIM...
This Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to examine the role of B cell-dependent regulatory T cells in maintaining B cell tolerance and preventing autoimmunity. The $807,799 award to the University of Chicago aims to identify B cell-dependent regulatory T cell clones, define their developmental requirements and functions, and determine the...
This federal Project Grant award of $125,000.00, issued by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), will support research to determine the structural mechanics underlying the functional differences between the Piezo1 and Piezo2 ion channels. The research aims to provide fundamental insights into how these mechanosensitive ion channels function within a cellular environment and establish a foundation...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) is funding research to investigate the role of mechanical cues in the extracellular matrix in regulating monocyte inflammation. The $406,250 award, which runs from January 1, 2025 to December 31, 2029, will support the development of human stem cell-based culture systems to study monocyte mechanobiology, the investigation of mechanical...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $379,823 to the University of California, Irvine (UCI) to conduct research on defining the mechanisms that drive novel cyclic nucleotide signaling in immune defense. The project aims to explore the evolutionary connections between cyclic nucleotide signaling pathways in diverse organisms, from bacteria to mammals, and delineate the...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,335,099 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) federal grant program to the University of Chicago. The 5-year award, effective September 2, 2024, will support research to identify the genetic instructions and processes that regulate long-distance interactions between enhancers and promoters, which are critical for gene expression control and have implications for human health. The...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $785,511 to the University of Chicago to conduct research on the genetic and epigenetic basis of inter-individual variation in immune responses to two deadly infectious agents, Mycobacterium tuberculosis and influenza virus. The key objectives are to: (1) characterize variability in immune responses to these...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $410,000.00 to the University of Chicago to conduct an in-depth investigation of bacterial secretion systems using cryo-electron tomography. The key focus areas are: 1) studying the assembly, disassembly, and function of the bacterial flagellar motor, a type III secretion system, and 2) deciphering the role of the type IV...
This federal Project Grant award of $644,900.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research on PAS (Period-ARNT-Single-Minded) domain proteins. The research aims to obtain mechanistic insights into how these ubiquitous signaling proteins, found across all kingdoms of life, detect and respond to changes in environmental conditions. Specifically, the research will utilize...