Project Grant R35GM154859

Award Date 7/15/24
Completion Date 6/30/29
Dollars Obligated $1.2M
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Cleveland, OH 44106, USA
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This $390,000 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to elucidate the mechanisms underlying DNA double-strand break repair. The project, led by researchers at Thomas Jefferson University, aims to provide a better understanding of the complex spatial and temporal organization of key proteins during DNA repair processes and how DNA damage accumulation can...
This federal Project Grant award of $1,637,500.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate the mechanisms that control DNA repair pathway choice. The principal investigator and awardee, The Johns Hopkins University, will pursue two complementary projects: 1) examining how the chromatin regulator MacroH2A1 isoforms affect DNA repair outcomes, and 2) exploring the...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $445,000.00 to support research on the molecular mechanisms of DNA double-strand break repair by homologous recombination. The award supports the long-term goal of defining the mechanisms of DNA double-strand break repair and contributing to improved treatments for diseases associated with defective DNA repair, such as breast...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $1,585,000.00 in funding to Trustees of Indiana University, doing business as Indiana University, for a project titled "Mechanism and Regulation of Homologous Recombination in Genome Maintenance". The award period runs from July 10, 2024 to April 30, 2029. The research aims to define the mechanism and regulation of DNA...
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This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $303,842 to The Washington University in St. Louis to conduct research on how the SMC5/6 complex protects replication forks from damage caused by the APOBEC3A enzyme during cellular mutagenesis. The 5-year project aims to define the impact of APOBEC3A activity on replication fork progression and elucidate the...
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This Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to advance the understanding of single-strand break (SSB) repair mechanisms within chromatin. The $1,207,500 award to Case Western Reserve University will support a 5-year research project to investigate how three key DNA repair proteins - PARP1, LIG3, and PNKP - recognize and repair SSBs in the context of nucleosomes. The research will employ DNA libraries, next-generation sequencing, biophysical tools, functional assays, and structural analysis techniques to map SSB accessibility, characterize protein-nucleosome interactions, and elucidate the interplay between post-translational histone modifications and SSB repair. The long-term goal is to provide a fundamental understanding of base excision repair mechanisms within nucleosomal contexts, which could inform the development of drugs and therapeutics for various disease states.

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