Project Grant R01GM154832
Award Date
7/10/24
Completion Date
4/30/28
Dollars Obligated
$1.3M
Federal Agency
National Institute of General Medical Sciences
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Cleveland, OH 44106, USA
Similar Awards
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $404,792 to Yale University to conduct research on the mechanisms regulating telomere length, protection, and replication. The project aims to gain new mechanistic insights into how telomeres are maintained and replicated, with potential implications for understanding and treating diseases like cancer and aging....
This Project Grant award of $2,046,670.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research on the structure and dynamics of telomeres and telomerase at the University of California, Santa Cruz (UCSC). The key products and services to be delivered through this 5-year project include: Advancing detailed mechanistic models for telomerase enzyme assembly, telomerase recruitment to telomeres, telomere...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $546,146 to Kent State University to conduct research on the structure, accessibility, and extension of telomeric overhangs. The primary objectives are to gain a mechanistic understanding of how the length, structure, and interactions of telomeric overhangs impact their accessibility to key regulatory factors like telomerase, nucleases,...
This $2.77 million project grant from the Department of Health and Human Services' Assistant Secretary for Financial Resources will support research at the University of Wisconsin-Madison to develop new single-molecule tools to characterize the human telomere chromatin landscape. Over three years, the researchers will establish proof-of-concept experiments using non-native DNA methylation to map protein-DNA interactions at repetitive telomeric DNA regions. They will then use these new tools to...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $933,000.00 in funding to the University of Wisconsin System to study the molecular mechanism of the human telomere C-strand fill-in machinery. The key objectives are to: 1) establish a consensus template sequence for the CST-POLA-primase assembly and C-strand synthesis initiation; 2) use cryo-EM to determine the...
This Project Grant award from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences, under the Biological Sciences program (CFDA 47.074), provides $910,000 over 4 years to Weill Medical College of Cornell University to conduct research on the regulation of DNA repair mechanisms and transcription at telomeres. The research aims to improve understanding of how genetic information is protected at chromosome ends, which is critical for cell and organism health. The...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award of $1,000,000 to the University of Michigan provides funding from August 1, 2024 to July 31, 2028 to study the molecular mechanism of telomere maintenance in the model organism Caenorhabditis elegans. The research aims to leverage the simplicity of the worm's shelterin protein complex to answer fundamental questions about the structure and function of these proteins in chromosome end protection and...
This $1,130,010 Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) will fund a study on the molecular mechanisms and evolutionary significance of natural telomere length variation in the plant monkeyflower (Mimulus). The 5-year research project aims to investigate how telomere length affects cellular development and stem cell differentiation, and how this relationship drives the adaptive evolution of...
This $462,500 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to develop chemical modulators of RNA-protein assemblies through the targeting of DEAD-box RNA-dependent ATPases. The research aims to generate selective inhibitors that can allosterically regulate RNA affinity, with the goal of propelling biological studies of RNA-protein complexes and potentially leading to...
The National Institute of General Medical Sciences (NIGMS) awarded a $357,666 Project Grant (CFDA 93.859 Biomedical Research and Research Training) to the University of Missouri System to study the coordination of complex dynamics by DNA manipulating enzymes. Over the 5-year project period from July 1, 2025 to May 31, 2030, the researchers will use a combination of single-molecule force and fluorescence measurements, as well as computational methods, to investigate the activity and...