The National Institute of General Medical Sciences (NIGMS) awarded a $344,400 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The University of Texas Southwestern Medical Center to develop new tools and approaches for improving cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) imaging techniques. Specifically, the grant aims to: 1) Develop a sample preparation strategy to reduce electron-induced radiolysis of frozen-hydrated biological...
This $390,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) will support the development of a multiparametric fluorescence microscopy framework to correlate metabolic changes with cellular manipulations and physical/biophysical properties. The award, granted to Georgetown University, will establish a seamless workflow to quantify and correlate fundamental cellular interactions, such as...
The National Institute of General Medical Sciences (NIGMS) awarded a $333,048 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Imagen Bioworks Inc. in Houston, TX. The goal of this 1-year project is to develop a versatile 2-photon microscopy platform, dubbed 2P-SPOTLIGHT, to isolate individual cells from 3D tissue samples and 3D cell cultures based on their spatial and temporal properties. This will enable researchers to conduct downstream multi-omics...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $541,967 to the University of Chicago to investigate the mechanical behaviors of cells and their impact on physiological processes and diseases. The research aims to expand the understanding of adherent cell mechanics and mechanobiology, focusing on the force-sensitive remodeling of cell-cell adhesions and the role of LIM...
This $1,444,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop new cryogenic electron microscopy (cryo-EM) methods to visualize the structural heterogeneity of ribosomes at the single-molecule level in cells. The award, effective September 2, 2024 through August 31, 2027, will enable the principal investigator to pursue strategies to extend a novel technique called 2D template...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,465,164 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Illinois. The grant supports the development of new super-accurate and super-resolved fluorescence microscopy techniques and probes for studying single molecular motors, such as kinesin, dynein, and myosin. Key focus areas include measuring conformational changes in these motors with nanometer and...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $374,399 in funding to the University of California, Davis to develop innovative two-photon microscopy systems with scattering correction capabilities for deep tissue imaging. The goal of this research is to enable high-speed, high-resolution imaging through scattering biological tissues, such as intact mouse organs, by...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $526,451 to the University of Maryland, College Park to develop a novel optical microscopy modality for cell biomechanics based on pulsed stimulated Brillouin scattering (SBS). The key objectives are to maximize the throughput of SBS microscopy, validate the modulus estimation from SBS characterization, and field-test the high-speed SBS...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,085,690 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Medical College of Wisconsin, Inc. (MCW) to purchase an Abberior 3D-STED super-resolution microscope. This high-end imaging system will be installed at MCW's Advanced Cell Imaging Core and will support the research of 14 well-funded NIH investigators across diverse biomedical fields such as cell biology, neuroscience, and...
The National Institute of General Medical Sciences (NIGMS) awarded a $330,076 Project Grant to Trestle Optics LLC under the Biomedical Research and Research Training (CFDA 93.859) federal grant program. The grant funding will support the development of a photothermal microscopy platform that can non-destructively profile metabolites in individual cells. The project aims to integrate photothermal microscopy with spatial light interference imaging to create a system capable of real-time,...