The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $187,831 Project Grant (CFDA #93.286 - Discovery and Applied Research for Technological Innovations to Improve Human Health) to the University of California, Davis to develop a miniature two-photon microscope that can simultaneously perform high-resolution calcium imaging and optogenetic manipulation of neural activity in freely-behaving mice. The project will integrate innovative beam forming techniques into a...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop computational microscopy technologies that can overcome the challenge of tissue scattering to enable large-scale 3D imaging of tissue morphogenesis. The $337,326 award to the University of Texas at Austin will fund research to: (1) develop computational scattering models for reconstructing 3D...
This federal Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $942,983 to acquire a Bruker Luxendo TruLive3D light-sheet microscope system. The award, effective September 1, 2024 through August 31, 2025, will enable rapid 3D volumetric imaging of live specimens such as mouse, fly, and zebrafish embryos with high resolution and minimal phototoxicity. This advanced microscope system will benefit a user group of...
This Project Grant award, titled "CAREER: Integrated Multiphoton-Phase Microscopy for Simultaneous and Correlative Imaging of Neurovascular Coupling Dynamics," was provided by the National Science Foundation's (NSF) Engineering program (CFDA 47.041). The $583,679 award aims to develop an innovative microscopy system capable of simultaneously imaging various aspects of the brain to better understand the link between neurons and blood vessels. This will help advance the understanding...
This $390,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) will support the development of a multiparametric fluorescence microscopy framework to correlate metabolic changes with cellular manipulations and physical/biophysical properties. The award, granted to Georgetown University, will establish a seamless workflow to quantify and correlate fundamental cellular interactions, such as...
The National Institute of General Medical Sciences (NIGMS) awarded a $291,224 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Chicago to develop BRAVE-EM, a novel imaging technique that combines the wavelength specificity of optical light microscopy with the spatial resolution and volume imaging capabilities of electron microscopy. This 5-year research program, starting on August 15, 2024, seeks to enable simultaneous functional and structural imaging...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $1,337,953.41 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to the University of Arizona. The grant supports the development and dissemination of an advanced 2-photon Bessel beam light sheet (2PBLS) microscopy instrument for high-speed, sub-micron resolution volumetric imaging in deep tissue. Key objectives include achieving...
This $1,444,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop new cryogenic electron microscopy (cryo-EM) methods to visualize the structural heterogeneity of ribosomes at the single-molecule level in cells. The award, effective September 2, 2024 through August 31, 2027, will enable the principal investigator to pursue strategies to extend a novel technique called 2D template...
This Project Grant award of $1,249,099 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) supports the development of a new class of small, bright, tunable, and biocompatible near-infrared (NIR-II) fluorescent probes for deep tissue molecular imaging. The University of California, Irvine (UC Irvine) will create a palette of DNA-stabilized silver nanoclusters (AgN-DNA) that emit in the NIR-II tissue transparency window (1,000-1,700 nm). These new...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $952,862 to the University of Rochester to develop flexible, multi-wavelength fiber optic light sources for advanced nonlinear and multimodal imaging. The key objectives are to: (1) create diode-laser driven fiber time-lens picosecond sources with fiber parametric amplification for flexible, multi-wavelength picosecond...