This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $812,500 in funding to The Trustees of the University of Pennsylvania (UPenn) to conduct research on RNA regulation and noncanonical translation between cell states. The research aims to map post-transcriptional regulation and the unannotated proteome, including RNA localization and modifications, to better understand how...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $393,093 to The Trustees of Columbia University in the City of New York to uncover the interplay between gene expression, cell morphometrics, and tissue-level mechanics during embryonic development. The research aims to develop an integrative, statistical machine learning framework for 4D mammalian development, leveraging...
This Project Grant award from the National Institutes of Health (NIH) Office of the Director under CFDA 93.310 "Trans-NIH Research Support" provides $1,463,997.00 in funding to The Trustees of Columbia University in the City of New York to develop a "Programmable Depletion and Rescue Platform to Screen Dynamic Regulatory Events During Cellular Differentiation." The project aims to explore specialized RNA degradation complexes that control the decay of specific mRNA subclasses...
The National Institute of General Medical Sciences (NIGMS) awarded a $411,250 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The Trustees of Columbia University in the City of New York, Health Sciences Division, to investigate the mechanisms by which R-loops epigenetically regulate gene transcription in pluripotency, early development, and tissue homeostasis. The research aims to establish a coherent view of regulatory R-loops as DNA and histone epigenetic...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $411,250 to The Trustees of Columbia University in the City of New York to conduct research on the interactions between membrane-bound organelles, such as lysosomes, and membrane-less organelles, such as RNA granules. The overarching goal is to understand how these two types of cellular compartments coordinate to maintain RNA...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $678,000.00 to Rockefeller University to conduct research on the mechanisms of eukaryotic ribosome assembly. The project aims to develop a detailed understanding of the co-transcriptional assembly and maturation of ribosomal subunits in the nucleolus, a crucial but poorly understood early stage of eukaryotic ribosome biogenesis. The...
This $1,084,158 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the University of Michigan's research efforts to investigate RNA-protein interactions (RPIs) and develop enabling technologies. Specifically, the grant funds three major research directions: 1) Further development of the university's live-cell RPI assay technology, RNA Interaction with Protein-mediated Complementation Assay...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $410,000.00 to The Trustees of Princeton University to develop advanced computational models to characterize the molecular structures and interactions within biomolecular condensates, with a focus on stress granules. The research aims to: 1) map the structures of RNA-binding proteins to stress granule properties, 2)...
This $504,175 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research on the role of non-coding RNA in regulating pluripotent stem cell biology and differentiation. The project, led by Yale University, leverages studies of adult pluripotent stem cells in planarians to investigate how piwi-interacting RNAs (piRNAs) and their binding partners, the piwi proteins, contribute to...
This Project Grant award, valued at $1,380,568.00 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program, supports an interdisciplinary research initiative led by the University of Chicago. The project aims to develop a multiscale, predictive understanding of how cells adapt to changes in their environment, with potential applications in innovative therapeutic interventions for diseases. The research is...