This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $1,102,648 to The Trustees of Columbia University in the City of New York, doing business as Columbia University, to conduct research on how the dynamic molecular interactions of RNA-binding proteins (RBPs) drive post-transcriptional gene expression changes during embryonic stem cell differentiation. The research aims to globally map...
The federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $1,507,500 to the University of Massachusetts Medical School (UMass Medical) to expand the capabilities of third-generation DNA/RNA sequencing technologies. The project aims to generate rapid and cost-effective training libraries to allow for direct detection of common DNA damage and RNA modifications, enabling innovative...
The National Institutes of Health Office of the Director awarded The Trustees of Princeton University a $2,877,560 project grant under the Trans-NIH Research Support program (CFDA 93.310) to build a systematic, comprehensive mammalian cell fate map from September 1, 2022 to August 31, 2025. Leveraging single-cell RNA sequencing and CRISPR-Cas9 genome editing, Princeton University will establish an evolving lineage tracing platform capable of recording mammalian differentiation processes at...
This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $393,093 to The Trustees of Columbia University in the City of New York to uncover the interplay between gene expression, cell morphometrics, and tissue-level mechanics during embryonic development. The research aims to develop an integrative, statistical machine learning framework for 4D mammalian development, leveraging...
This $588,426 Project Grant award, provided by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), aims to investigate how transcription factors efficiently locate and bind to specific DNA binding sites within the crowded nucleus of living cells. The project will employ advanced microscopy techniques to precisely track the 3D diffusion, DNA interactions, and target site discrimination of transcription factors involved in...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA 93.859 Biomedical Research and Research Training program, provides $162,874 to The Trustees of Princeton University to conduct research on the regulation of protein dynamics in the ectoderm germ layer of Drosophila embryos. The key objectives are to: Quantify proteome differentiation and stochastic cell fate diversification using deep multiplexed proteomics and single-cell RNA sequencing (Aims...
This Project Grant award of $388,621 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support the development of novel molecular designs with therapeutic potential. The key objectives are: Developing ligand-heterocycle conjugates as targeted RNA degraders with rapid kinetics and selectivity for cancer-associated G-quadruplexes. Engineering nucleic acid polymers with (thio)phosphoramidate backbones as biostable...
This $133,401 Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), seeks to develop computational models that can identify the sequence of changes cells undergo during differentiation and maturation. The goal is to compare changes in gene expression and chromatin accessibility to understand how these modalities coordinate to drive cellular...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $380,587 to The Johns Hopkins University from January 1, 2025 to December 31, 2029. The project aims to develop new integrated technologies to investigate how distinct molecular programs drive cell behaviors and cellular responses to perturbations at single-cell resolution. The research will focus on understanding...