This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), supports research on the "Behavioral and Neurobiological Mechanisms of Reciprocal Social Interactions in Substance Use Disorders." The $641,450 award to the University of Maryland, Baltimore aims to study how drug use, particularly heroin, leads to social isolation as partners fail to reciprocate social interactions. The research will...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), will provide $391,833 to the Icahn School of Medicine at Mount Sinai to conduct preparatory research activities. The goal is to establish the feasibility and validity for a future project examining the impact of juvenile social isolation on the maturation of the prefrontal cortex circuit and substance use disorder-relevant behaviors. The preparatory...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), will support a $346,911 cross-species research study to identify early life environmental and genetic risk factors for substance use disorders (SUDs). The key objectives are to: 1) determine how early life environment influences neurocognitive development and its relationship to adult impulsivity behaviors; 2) identify genomic networks associated...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to develop a translational rat model of the neonatal intensive care unit (NICU) experience and its impacts on substance use disorder risk. The $368,315 award to the Georgia State University Research Foundation will: 1) design and test a model combining early pain, resource scarcity, and separation from caregivers to mimic key aspects of...
This $2,419,326 Project Grant awarded by the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports a longitudinal study to investigate neurobehavioral and psychosocial predictors of health risk behaviors (HRBs) in adolescence and young adulthood. The primary awardee, Virginia Polytechnic Institute & State University, will conduct assessments over 15 years to understand brain development and its impact on substance use and...
This $284,040 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to conduct integrated single-cell and spatial mapping of the habenula circuitry to identify projection-specific molecular pathways associated with opioid exposure. The Lieber Institute for Brain Development in Baltimore, MD will lead this research effort from September 1, 2024 to August 31, 2026. The project will generate a...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,073,250 to the University of California, San Diego (UCSD) to investigate age-related differences in opioid reward and addiction. The funded studies will use rat models to determine how the middle-adult developmental stage may influence sensitivity to prescription opioids, heroin, and fentanyl, compared to younger adulthood. The research aims...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $419,876 to conduct preclinical trials targeting the neuropeptide S (NPS) receptor to mitigate opioid taking and seeking behaviors in animal models. The goals of the project are to demonstrate proof-of-concept that NPS receptor-targeted molecules can reduce oxycodone self-administration and motivation in rats, which could inform the...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund research to investigate the role of cholinergic interneurons in the ventral tegmental area on opioid-related behaviors. The $373,181 grant, awarded on July 15, 2024 with a completion date of June 30, 2027, aims to determine whether mu-opioid receptors on cholinergic interneurons contribute to opioid reward, consumption, and withdrawal, and how...
This $161,664 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support the development of a behavioral arena and computational framework to study social behaviors in Lake Malawi cichlids. The project aims to create tools to track animals and measure social behavioral dynamics within a natural environment mimicking context, including factors like hierarchy and male displays. This work will generate new...