Project Grant R21TR006271
- Federal Grant Award Summary Epitune LLC received a $350,000 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded September 16, 2025, with completion targeted for February 28, 2026. The award supports the development of a novel imaging-based platform for single-cell quality and identity control of human-induced pluripotent stem cells (hiPSCs) and other cell types used in cell-based...
- Federal Project Grant Award Summary The Washington University received a $1.39M Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective September 1, 2025, through August 31, 2028. This award funds research on time-lapse epigenome profiling to advance cellular reprogramming technologies. The project will develop and apply novel methodologies to capture real-time snapshots of heterochromatin...
- Federal Grant Award Summary Intero Biosystems Inc. received a $349,952 Project Grant from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) awarded on June 20, 2025, with a completion date of June 19, 2026. In collaboration with the University of Michigan, the awardee is developing and validating a novel stem cell-derived human intestinal organoid (HIO) screening platform designed to improve preclinical drug testing and reduce the current 90% failure rate of drug...
- Federal Project Grant Summary The National Institute of Child Health and Human Development (NICHD) awarded The Washington University a $657,377 Project Grant effective September 1, 2025, through May 31, 2030, under the Child Health and Human Development Extramural Research program (CFDA 93.865). This award funds research to advance understanding of human trophoblast development and function using pluripotent stem cell models. The research addresses critical gaps in knowledge regarding...
- Federal Project Grant Award Summary Cisterna Biologics, Inc. received a $349,746 project grant award from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) effective August 1, 2025, through July 31, 2027, to develop and validate an innovative mRNA purification platform. Under this Phase I Small Business Innovation Research (SBIR) grant, Cisterna will demonstrate the efficacy of its technology in eliminating three primary mRNA contaminants—double-stranded RNA...
- Federal Grant Award Summary The National Institute of Child Health and Human Development awarded The Washington University a $652,723 Project Grant (CFDA 93.865: Child Health and Human Development Extramural Research) on August 14, 2025, with a completion date of April 30, 2030. The research project delivers preclinical testing services and scientific expertise related to early-life anti-myostatin therapy for osteogenesis imperfecta (OI), a genetic connective tissue disorder characterized by...
- Federal Grant Award Summary The National Institute of Child Health and Human Development awarded Washington University a $1,141,436 Project Grant effective September 1, 2025, through August 31, 2030, under the Child Health and Human Development Extramural Research program (CFDA 93.865). This award funds research to advance understanding of spatiotemporal control mechanisms in transcutaneous spinal cord stimulation (TSCS) for individuals with spinal cord injury (SCI). The research will generate...
- Federal Project Grant Summary The National Institute of General Medical Sciences (NIGMS) awarded The Washington University a $2.78 million Project Grant (CFDA 93.859: Biomedical Research and Research Training) effective September 1, 2025, through August 31, 2029. This award supports fundamental basic research investigating the role of the ribosome and translation factors in mediating cellular stress signaling. The research focuses on understanding how cells recognize and respond to chemical...
- Federal Project Grant Award Summary The Washington University received a $483,175 Project Grant award effective June 1, 2026, through January 1, 2031, from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant funds fundamental basic research to elucidate mechanosensitive mechanisms that regulate cellular transcription and cell-to-cell signaling during tissue morphogenesis and patterning. The research...
- Federal Grant Award Summary Capienda Biotech, LLC received a $329,272 Project Grant from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) awarded on August 1, 2025, with a completion date of July 31, 2026. The award funds development of a high-throughput kinetic screening instrument designed to accelerate small-molecule drug discovery. Building on Phase I Small Business Innovation Research (SBIR) success, Capienda will upgrade its prototype platform to enable...
The National Center for Advancing Translational Sciences (NCATS) awarded The Washington University $427,625 on May 1, 2026, under CFDA 93.350 to develop an integrated modular biomanufacturing and cryopreservation platform for scalable production of clinical-grade human induced pluripotent stem cell (hiPSC) therapies. This exploratory R21 award addresses critical manufacturing bottlenecks in translational regenerative medicine by engineering a low-shear, perfusion-based bioreactor system coupled with controlled-rate cryopreservation technology. The deliverables include optimization of a multilayer perfusion bioreactor supporting hiPSC expansion at clinical scales with defined operational parameters, validated protocols for efficient cell harvesting and redeployment across multiple hiPSC lines, and long-term culture strategies that preserve genomic stability and pluripotency through multiple passages. The research will also establish cryopreservation workflows using cryobags and controlled-rate freezing technology, with comprehensive post-thaw assessment of cell viability, genomic integrity, and differentiation potential. Upon completion by April 30, 2028, the project will deliver the first integrated, current Good Manufacturing Practice (cGMP)-compatible platform for low-shear expansion and cryostorage of hiPSC-derived therapeutic products, establishing technical feasibility and foundational workflows for a generalizable manufacturing system applicable to diverse regenerative medicine and cell-based therapeutic applications.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $427.6k | 4/29/26 |