Project Grant R35GM158294
- The National Institute of General Medical Sciences (NIGMS) awarded a $854,927 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Washington University in Missouri. The grant, effective September 5, 2025 through August 31, 2027, will support research to define the mechanisms of a new pathway for genome stability, known as RNA Damage Induced DNA Breaks (RDIBS). The key objectives are to identify the types of RNA modifications that activate RDIBS, the...
- This federal Project Grant award, valued at $372,880 and issued on May 1, 2025, is funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports a research project aimed at understanding how cells regulate protein synthesis to maintain homeostasis during cellular stress. The key focus is on investigating the role of the translation initiation factor eIF2 and its phosphorylation in modulating gene...
- This $316,968 federal Project Grant was awarded on June 1, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports fundamental scientific research and advanced training focused on understanding the regulation, inhibition, and quality control mechanisms of ribosomes, which are the cellular machinery responsible for protein synthesis. The key research areas include translation fidelity,...
- The Johns Hopkins University was awarded a $2,136,693 Project Grant from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) to conduct research on the "Molecular Mechanisms of Ribosome-Mediated Kinase Signaling". The 4-year project, which commenced on September 1, 2025, aims to define the molecular mechanisms by which two specific cellular kinases, GCN2 and ZAK, interact with ribosomes to activate downstream stress...
- This federal Project Grant award for $678,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to understand the molecular mechanisms governing the assembly of eukaryotic ribosomes. The research aims to define the co-transcriptional assembly events and transitions towards stable post-transcriptional nucleolar assembly intermediates of ribosomal subunits, leveraging advanced...
- This federal Project Grant award of $125,000 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of Colorado. The project, titled "Intermolecular RNA-RNA Interactions in Stress Granule Regulation and Disease," aims to determine how the stress granule scaffolding protein G3BP1 facilitates the formation of intermolecular RNA-RNA interactions, identify the...
- This federal Project Grant award of $440,454 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to The Washington University in University City, Missouri. The award will support research on how epithelial cells in mechanically heterogeneous microenvironments, such as those found in the gut, lungs, and skin, sense and respond to both mechanical and biochemical cues in the extracellular matrix. Key...
- This federal Project Grant award of $1,943,750.00, awarded on August 8, 2025, is provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports fundamental research and advanced training focused on understanding the molecular mechanisms that regulate the mitotic DNA damage response. The project, led by researchers at The Washington University, aims to 1) reveal how ubiquitinated histone H2A acts...
- This Project Grant award, valued at $379,394.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports a research project investigating the mechanisms by which human cells detect and respond to oxidative stress, with a focus on understanding the dose-dependent activation of key stress response proteins. The research aims to uncover how dynamic stress response pathways influence cell...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $416,050 to The Washington University in University City, Missouri to conduct research on understanding the metabolic and regulatory control of antibiotic production in filamentous actinobacteria. The research aims to investigate two families of antibiotic molecules - polycyclic tetramate macrolactams and...
This Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate how cells respond and adapt to environmental stresses. The $2,777,852 award to The Washington University, located in University City, Missouri, will fund a 4-year research project to study the role of the ribosome and translation factors in mediating stress signaling pathways. The research aims to examine the mechanisms by which cells recognize and degrade chemically damaged ribosomes, a process that may have implications for disease states and certain medical treatments. The findings from this fundamental scientific investigation have the potential to advance the understanding of cellular homeostasis and the regulation of stress response pathways.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.8m | 8/14/25 |