Project Grant R01HD119966
- The University of Missouri System, doing business as the Curators of the University of Missouri, was awarded a $217,371 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant will fund preclinical testing of early life anti-myostatin therapy for treating osteogenesis imperfecta (OI), a connective tissue disorder resulting in muscle weakness, bone deformity, and...
- This $667,125 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846), aims to develop a long-lasting, bone-targeted gene therapy for Osteogenesis Imperfecta (OI), the most common bone fragility disease. The University of Massachusetts Medical School (UMMS) will use a novel recombinant adeno-associated virus (rAAV) vector with bone-specific...
- This Project Grant award of $999,593.00 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to improve understanding of oxytocin receptor (OXTR) function and dynamics. The key objectives are to quantitatively define the trafficking of the OXTR in uterine smooth muscle (myometrial) cells, including membrane insertion, internalization, and recycling. This...
- This federal Project Grant award of $234,000 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate the underlying mechanisms driving obesity and metabolic disorders in offspring of obese mothers. The research, conducted by Oregon Health & Science University, aims to leverage a mouse model to elucidate how maternal high-fat diet...
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $302,500 Project Grant to Myogene Bio LLC, a woman-owned small business in San Diego, California. The grant, provided under NICHD's Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to assess the use of a restored dystrophin protein as a biomarker for evaluating the efficacy of a gene editing therapy for Duchenne muscular dystrophy (DMD). The...
- This $159,594 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to identify new therapeutic targets for osteogenesis imperfecta (OI), a rare genetic bone disorder. The award recipient, the Research Foundation of the City University of New York (RFCUNY), will investigate the intracellular signaling and extracellular matrix mechanisms...
- This Project Grant award, valued at $643,049.00, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports the development of a physiomimetic model of endometrioma, a type of endometriotic lesion, to study processes driving lesion initiation, ovarian stroma invasion, and persistence in a chronic inflammatory environment. The research aims to uncover...
- This $451,000 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 - Child Health and Human Development Extramural Research will support research to elucidate the role of the KBTBD2 gene in bone development and its relation to the genetic disorder Short Syndrome. The key objectives are to: 1) Determine the molecular mechanism by which KBTBD2 regulates bone development through its interaction with the p85a subunit of PI3K, a key...
- This $687,427 Project Grant awarded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Federal Grant Program 93.865 - Child Health and Human Development Extramural Research, aims to investigate the role of macrophages in guiding digit regeneration. The project leverages a comparative mouse model of bone regeneration and scar formation to study a unique population of macrophages that associates with growing bone and expresses growth factors...
- This $177,000 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research (CFDA 93.846) program, supports research to investigate genetic determinants of chondrocyte maturation and its impact on skeletal growth disorders. The research at Boston Children's Hospital, a premier pediatric medical research institution, leverages a high-throughput screening approach to identify novel...
This Project Grant award, totaling $652,723.00, was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports preclinical research to evaluate the efficacy of an innovative in utero pharmacological approach using anti-myostatin monoclonal antibody therapy to improve bone and muscle strength in offspring with Osteogenesis Imperfecta (OI), a genetic connective tissue disorder. The research, to be conducted at The Washington University in Missouri, aims to test this early life anti-myostatin therapy in two distinct mouse models of OI, with the goal of developing a therapeutic intervention that can be applied during pregnancy and early childhood to address the muscle weakness, bone deformity, and increased fragility associated with this condition. The award period runs from August 14, 2025 through April 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $652.7k | 8/14/25 |