Project Grant R01HD119277
- The National Institute of Child Health and Human Development (NICHD) awarded a $411,125 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Syracuse University to develop a microfluidic human placenta organoid model. The goal is to generate human trophoblast stem cells (HTSCs) from induced pluripotent stem cells and use them to create a placenta organoid system that can replicate early/mid-gestation placental development. The researchers will study the role of...
- This federal Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is supporting research at Duke University to investigate the mechanisms behind nuclear plasticity and adaptation in the human placental syncytiotrophoblast (STB) during pregnancy. The $121,515 award, with a period of performance from August 1, 2025 to July 31, 2027, aims to...
- This federal Project Grant award, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to understand the mechanism of pluripotency transitions during peri-implantation development. The $760,617 award to The Children's Hospital Corporation, doing business as Boston Children's Hospital, aims to address the technical challenges in working with limited...
- This $163,145 Project Grant awarded on August 7, 2025 by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research Program (CFDA 93.865), aims to address critical questions pertaining to impaired placentation associated with fetal growth restriction (FGR). The principal investigator, a pediatric and fetal surgeon, will use this 5-year award to develop unique cross-disciplinary skills and...
- The federal Project Grant award of $429,000 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to characterize placental extracellular vesicles (EVs) throughout human pregnancy. The goal is to develop novel methods to image, count, isolate, and validate placental cell- and size-specific EVs from maternal blood, in order to monitor placental...
- This Project Grant, awarded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), focuses on elucidating the role of the Protein Arginine Methyltransferase 1 (PRMT1) gene in regulating trophoblast development and placentation during pregnancy. The $426,250 award will support two specific aims: 1) Using a conditional PRMT1 knockout mouse model, the researchers will...
- This federal Project Grant award for $152,816.00, provided by the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research), aims to investigate the link between Down's syndrome (trisomy 21) and placentation defects. The research will focus on: Identifying transcriptional differences in implantation-stage trophoblasts between trisomy 21 and euploid induced pluripotent stem cell lines through RNA-sequencing. Assessing the...
- This $156,500 Project Grant was awarded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), to the University of Hawaii at Manoa. The objective is to create an in vitro 3D model of the human yolk sac using human pluripotent stem cells, with the goal of studying the impact of environmental and genetic factors on this critical embryonic structure. The project will...
- The Project Grant award titled "UNDERSTANDING FUNCTIONS OF LTR RETROTRANSPOSON ACTIVATION IN PREIMPLANTATION DEVELOPMENT" is funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $401,927 award supports research to understand how long terminal repeat (LTR) retrotransposons regulate zygotic gene activation and early embryogenesis. The research...
- This $429,000 federal Project Grant award, funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate the gene and environmental influences on placental angiogenesis and severe fetal growth restriction. The University of Colorado-Denver, the awardee organization, will leverage induced pluripotent stem cell technology to better...
This Project Grant award of $657,377 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to model human trophoblast differentiation and function using pluripotent stem cells. The primary objectives are to: 1) establish an epigenome roadmap during the transition from naive human pluripotent stem cells (hPSCs) into human trophoblast stem cells (HTSCs) and their subsequent differentiation into specialized trophoblast cell types; and 2) define a core transcriptional regulatory network driving trophoblast lineage specification and function. This research aims to improve understanding of early human placental development, with the goal of advancing diagnosis and treatment of placental complications. The award period runs from September 1, 2025 to May 31, 2030 and the work will be conducted by the Washington University.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $657.4k | 8/29/25 |