This federal Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $261,017 to The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. to develop a new mouse model system for targeted trimming of disease susceptibility loci. The project aims to streamline the identification of causative genes within large susceptibility loci, which is a major challenge in biomedical research. By generating two new...
This Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $844,954 to New York University School of Medicine to develop "Genomically Rewritten and Tailored Humanized Mouse Models for Various Organ Disorders." The key objective is to leverage advanced DNA synthesis and editing technologies to create mouse models that accurately reflect human disease susceptibility and phenotypes. These...
This Project Grant award from the National Institutes of Health (NIH) Research Infrastructure Programs (CFDA 93.351) provides $240,039 to Baylor College of Medicine to develop a novel mouse model for detecting genome editing events. The project aims to create a more sensitive animal reporter system that can better monitor the efficiency and off-target effects of CRISPR/Cas9 genome editing, which is critical for evaluating new therapeutic applications. The innovative approach involves fusing...
This federal Project Grant award from the National Institutes of Health (NIH) Office of the Director (CFDA 93.351 - Research Infrastructure Programs) provides $217,533 to the University of Wisconsin System to develop a multi-color, multi-loci mouse reporter system for tracking hematopoietic stem cells (HSCs) and multipotent progenitor cells (MPPs) in their natural microenvironment. The key objectives are to: 1) Generate an HSC/MPP reporter mouse line by knocking in fluorescent protein...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $627,797 to Cornell University to conduct research on the molecular mechanisms connecting endocytic and junctional complexes with epithelial pathology in C. elegans. The research aims to delineate the inner workings of membrane-associated protein complexes required for tissue form and function, and whose dysfunction leads to...
This Project Grant award, valued at $881,450.00, was provided by the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) to the University of Massachusetts Medical School (UMass Medical). The grant's objective is to develop novel humanized mouse models that can efficiently support the engraftment and development of human tissue-resident macrophages for use in research on human diseases, with a focus on HIV latency and Alzheimer's disease-related...
This $775,888 federal Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) will support the development and validation of a modular CRISPR-ready HLA transgenic mouse platform at the La Jolla Institute for Immunology. The key objectives are to: (1) produce a CRISPR-ready platform strain and HLA allele-specific transgenic mouse strains for autoimmune disease and common U.S. ethnic group HLA types, and (2) test and validate T cell...
This Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of novel statistical and computational methods for genetic epidemiology. The $346,582 award to Cornell University, commencing on January 1, 2025 and running through December 31, 2029, will fund research to: Create efficient coalescent-based phylodynamic methods to jointly infer pathogen genealogies and...
This Project Grant award from the National Cancer Institute under the Cancer Biology Research (CFDA 93.396) program provides $160,330 to the University of Illinois to develop novel lung adenocarcinoma models using genome-edited primary human lung stem and progenitor cells. The goal is to create organoid and in vivo tumor models that better capture the initiation, progression, and composition of primary human lung adenocarcinoma compared to existing mouse models. The researchers will introduce...
This Project Grant award, provided by the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351), aims to rapidly develop advanced mouse resource strains through the application of Prime Editing technology. The $265,500 award, granted on September 1, 2024, will fund research at the Jackson Laboratory to create a novel combinatorial system that can efficiently modify thousands of mouse genes by applying Prime Editing techniques. The key innovation is the...