This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $493,810 in funding to the University of Wisconsin - Madison to conduct research on hematopoietic stem and progenitor cell (HSPC) programming and fate decisions. The research aims to decode the mechanisms governing HSPC fate decisions and track their long-term impact on hematopoiesis, using zebrafish and mouse models. Specifically, the...
This $881,450 Project Grant awarded by the National Institutes of Health (NIH) Office of the Director under the CFDA 93.351 Research Infrastructure Programs provides funding to the University of Massachusetts Medical School to develop novel humanized mouse models that efficiently support the engraftment and development of human tissue-resident macrophages. The project aims to genetically modify NSG mouse strains to reduce mouse macrophage populations and express human cytokines, enabling...
This federal Project Grant award of $590,283 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to improve the robustness and reproducibility of human pluripotent stem cell (hPSC) differentiation into cardiomyocytes (CMs) through feedback-controlled closed-loop manufacturing processes. The key goals are to:
Identify 2D CM differentiation failure modes through integrated single-cell transcriptomics and epigenomics...
The Project Grant award R35GM155127, totaling $382,090, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The primary focus of this 5-year award to the University of Wisconsin - Madison is to investigate the role of human-specific genetic haplotype diversity in cell fate commitment and the maintenance of cell states. The research strategy involves utilizing induced pluripotent stem cells...
The University of Missouri System (the University) was awarded a $423,027 Cooperative Agreement from the National Institutes of Health (NIH) Research Infrastructure Programs (CFDA 93.351) with a project period from August 15, 2024 to July 31, 2026. The award establishes the MU Rodent Testing Center for Somatic Cell Genome Editing, which will provide critical services and resources to support the translation of genome editing technology into clinical applications. Key activities...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $390,000 to The Medical College of Wisconsin, Inc. over a 5-year period from 2025 to 2029. The objective of this research project is to improve the foundational knowledge of immune cell biology in vivo, focusing on the ontogeny, kinetics, and function of tissue-resident macrophages. The researchers will utilize a novel small and...
The National Institutes of Health Office of the Director awarded The Trustees of Princeton University a $2,877,560 project grant under the Trans-NIH Research Support program (CFDA 93.310) to build a systematic, comprehensive mammalian cell fate map from September 1, 2022 to August 31, 2025. Leveraging single-cell RNA sequencing and CRISPR-Cas9 genome editing, Princeton University will establish an evolving lineage tracing platform capable of recording mammalian differentiation processes at...
The Project Grant award R21OD036471, provided by the Department of Health and Human Services National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351), will be used by Seattle Children's Research Institute, a non-profit organization, to develop multiple genetic tools and establish the Acomys rodent as an experimentally and genetically tractable model for mammalian non-fibrotic regenerative healing research. The $293,550 grant, awarded on July 1, 2024, will...
This Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $1,630,964 to the University of Southern California (USC) to study the spatial organization and signaling dynamics of hematopoietic stem and progenitor cells (HSPCs) in the bone marrow.
The central objectives are to (1) map the spatial distribution of HSPCs, (2) investigate how their spatial positioning changes during hematopoiesis and in response to specific blood...
The National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) awarded a $375,430 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Wisconsin System, University of Wisconsin - Madison Division for the project "Regulation of RNA Condensates by RNA Helicases in Development." The five-year award, effective February 1, 2025 through December 31, 2029, will investigate the regulation of germ granules, an RNA...