Project Grant R21OD037867
- This Project Grant awarded by the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351) provides $844,954 to New York University School of Medicine to develop "Genomically Rewritten and Tailored Humanized Mouse Models for Various Organ Disorders." The project leverages advanced DNA synthesis and editing capabilities to create genetically engineered mouse models (GREAT-GEMMs) that accurately represent specific human disease phenotypes. These...
- This Project Grant award from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (ORIP) under CFDA 93.351 provides $490,145.00 to the University of Massachusetts to produce and validate monoclonal antibodies that can be used to study proteins in mouse, Xenopus, and axolotl animal models. The goal is to develop these critical research tools to enhance rigor and reproducibility in biomedical research using vertebrate animal models. The project will run from May 2025...
- This Project Grant award from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351) provides $775,888 to the La Jolla Institute for Immunology to develop a next-generation CRISPR-ready, HLA class I and II transgenic mouse platform. The goal is to create a modular, CAS9-expressing mouse strain from which investigators can generate HLA class I or II transgenic mice for a broad range of disease research, including infection, cancer, autoimmunity, and...
- This Project Grant award of $261,017.00 was provided by the National Institutes of Health (NIH) Office of the Director through the Research Infrastructure Programs (CFDA 93.351) to The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. The grant supports the development of a mouse model system for targeted trimming of disease susceptibility loci, which aims to streamline the identification of genes responsible for particular traits or diseases. The proposed approach...
- This Project Grant awarded by the U.S. Department of Health and Human Services National Institutes of Health Office of the Director, under the NIH Research Infrastructure Programs (CFDA 93.351), provides $240,039.00 to the Baylor College of Medicine to develop a novel mouse model for detecting genome editing using CRISPR/Cas9 technology. The project aims to create an improved animal model that can more accurately track and quantify on-target and off-target genome editing events, in order to...
- This federal Project Grant award of $451,000 was provided by the National Institutes of Health (NIH) Office of Research Infrastructure Programs (ORIP) under the Research Infrastructure Programs (CFDA 93.351). The award will fund the development and validation of a series of novel mouse models at Rhode Island Hospital, a division of Lifespan Corporation, to investigate the role of mechanotransduction - the ability of cells to sense and respond to mechanical stimuli - in the pathogenesis of...
- This federal Project Grant award of $779,657, funded by the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351 - Research Infrastructure Programs), aims to establish and expand community-accessible resources for site-directed transgenesis in zebrafish. The University of Colorado-Denver will replace existing Tol2-based transgenes with engineered PhiC31 integrase genomic loci (PIGLET) to create the first universal landing site strains for zebrafish,...
- The National Institutes of Health (NIH) Office of Research Infrastructure Programs (ORIP) awarded a $776,504 Project Grant on Aug 1, 2025 to the Regents of the University of Michigan to support the "National Center of Rabbit Models for Translational Research". The grant will fund the development and expansion of genetically engineered rabbit models for biomedical research applications over the 4-year project period ending on Jul 31, 2029. The grant aims to leverage the advantages of...
- This Project Grant award from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351 - Research Infrastructure Programs) provides $194,375 to the University of Wisconsin-Madison to develop robust genome editing tools for generating floxed alleles and editing amino acid changes in the zebrafish model system. The project aims to establish a synthetic exon-mediated integration approach to reliably introduce loxP sites into target genes, enabling...
- This federal Project Grant award from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351) provides $416,925 to Objective Biotechnology, Inc. to develop and evaluate a miniature, high-performance microscope system for imaging brain activity in freely behaving mice. The award period runs from September 15, 2025 to August 31, 2027. The key objectives are to engineer the "Mini-MScope" device with a highly sensitive imaging sensor, evaluate its...
The National Institutes of Health (NIH) Office of Research Infrastructure Programs (ORIP) awarded a $230,250 Project Grant under the Research Infrastructure Programs (CFDA 93.351) to the University of Nebraska Medical Center (UNMC) to develop and characterize new transgenic mouse models expressing red fluorescent protein (RFP)-based genetically encoded indicators. The goal is to make these RFP-based mouse models available to the scientific community to overcome limitations of commonly used green fluorescent protein (GFP) indicators, such as phototoxicity and tissue autofluorescence. UNMC will utilize a CRISPR-based genome engineering approach to generate two conditional knock-in mouse strains expressing RFP indicators, building on an existing GFP indicator mouse model. This 2-year project aims to create valuable new research resources for in vivo studies of cellular processes using advanced fluorescence microscopy techniques.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $230.3k | 7/31/25 |