This Project Grant award, funded by the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351), supports the expansion of conditional gene research resources for zebrafish, a leading model organism for human health studies. The $1,023,185 award, active from August 1, 2024 to July 31, 2028, will enable the prime recipient, Iowa State University, to develop advanced genome editing tools and a repository of Cre recombinase conditional alleles for studying...
This Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) aims to develop efficient methods for introducing single nucleotide polymorphisms (SNPs) and variants of uncertain significance (VUS) into the zebrafish genome. The $181,754 award to Iowa State University, effective from September 15, 2024 to August 31, 2026, will test the university's "GeneweldTM" gene editing approach to efficiently target the integration...
The U.S. National Institutes of Health (NIH) awarded a $607,682 Project Grant under the Research Infrastructure Programs (CFDA 93.351) to the Oklahoma Medical Research Foundation (OMRF) to develop advanced phenotyping and gene editing tools for functional studies in zebrafish disease models. The project aims to establish a high-throughput pipeline for generating and phenotyping 80 zebrafish disease models, as well as optimize and expand the targeting capabilities of CRISPR-based base editors...
This Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $769,325 to the University of Utah to develop advanced tools and resources for generating and characterizing disease models using zebrafish. Specifically, the project will leverage technologies like multiplexed CRISPR droplets (MIC-DROP), single-cell RNA sequencing, and automated physiological/behavioral assays to generate and analyze hundreds of zebrafish...
This $743,926 Project Grant was awarded on September 15, 2024 by the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351). The grant will support the development of a resource of rigorously validated, translatable zebrafish models of previously undiagnosed human genetic diseases. Through collaboration with clinical diagnostic centers, the project will analyze genetic variants from patients with rare diseases, generate humanized zebrafish models using...
The National Institute of General Medical Sciences (NIGMS) awarded a $349,999 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to the University of Maine System's University of Maine division. The grant will be used to expand the university's zebrafish research facility, which is critical to the success of 12 NIH-funded faculty across multiple departments. The funding will be used to purchase a central filtration system, 11 double-sided racks, and an...
This federal Project Grant award, funded by the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351), aims to generate new animal models for studying mitochondrial DNA (mtDNA) diseases. The $629,508 grant, awarded to the University of Texas at Austin, will be used to accomplish three key objectives: Develop designer zebrafish models harboring specific mtDNA variants to study the differential roles of genetic variation in mitochondrial biology and...
This Project Grant award from the National Human Genome Research Institute (NHGRI), under the Human Genome Research federal grant program (CFDA 93.172), supports a project titled "Integrated Multimodal Phenotyping of Zebrafish Models of Human Cognitive Disorders". The $162,461 award, with a project period from Sep 2024 to Aug 2029, aims to generate knockout mutants for 61 transcriptional regulators associated with human cognitive disorders using CRISPR-based technologies. The principal...
The National Institutes of Health (NIH) awarded a Project Grant under the Research Infrastructure Programs (CFDA 93.351) to The Ohio State University in the amount of $337,482.00 on June 15, 2024. The goal of this grant is to enable a comprehensive modernization of the aging zebrafish research facility in Bevis Hall at The Ohio State University. The proposed renovations will include automatic monitoring and control of critical water parameters, automatic feeding systems, centralized water...
This federal Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $265,500 to the Jackson Laboratory to rapidly develop mouse resource strains through the application of prime editing technology. The key objectives are to leverage prime editing, a novel CRISPR-based gene editing approach, to efficiently modify and functionally tag thousands of mouse genes without the need for labor-intensive microinjection methods. The...