Project Grant R21OD037863
- This Project Grant award of $261,017.00 was provided by the National Institutes of Health (NIH) Office of the Director through the Research Infrastructure Programs (CFDA 93.351) to The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. The grant supports the development of a mouse model system for targeted trimming of disease susceptibility loci, which aims to streamline the identification of genes responsible for particular traits or diseases. The proposed approach...
- This $128,500 federal Project Grant award was provided by the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) to the Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. The funding will support the purchase of a new efficient sterilizer with a water conservation vacuum system to increase the Institute's capacity for reliably sterilizing animal cages and research materials. This will enable the Institute to better support...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) is funding research to investigate the role of mechanical cues in the extracellular matrix in regulating monocyte inflammation. The $406,250 award, which runs from January 1, 2025 to December 31, 2029, will support the development of human stem cell-based culture systems to study monocyte mechanobiology, the investigation of mechanical...
- This Project Grant awarded by the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351) provides $844,954 to New York University School of Medicine to develop "Genomically Rewritten and Tailored Humanized Mouse Models for Various Organ Disorders." The project leverages advanced DNA synthesis and editing capabilities to create genetically engineered mouse models (GREAT-GEMMs) that accurately represent specific human disease phenotypes. These...
- The National Institutes of Health (NIH) Office of Research Infrastructure Programs (ORIP) awarded a $230,250 Project Grant under the Research Infrastructure Programs (CFDA 93.351) to the University of Nebraska Medical Center (UNMC) to develop and characterize new transgenic mouse models expressing red fluorescent protein (RFP)-based genetically encoded indicators. The goal is to make these RFP-based mouse models available to the scientific community to overcome limitations of commonly used green...
- This Project Grant award from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (ORIP) under CFDA 93.351 provides $490,145.00 to the University of Massachusetts to produce and validate monoclonal antibodies that can be used to study proteins in mouse, Xenopus, and axolotl animal models. The goal is to develop these critical research tools to enhance rigor and reproducibility in biomedical research using vertebrate animal models. The project will run from May 2025...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA Program 93.859 Biomedical Research and Research Training, provides $406,250.00 to the University of Massachusetts to develop sophisticated mathematical models, particularly using partial differential equations (PDEs), to investigate the spatial interactions between cells and molecules within tissues. The models aim to capture tissue-specific biochemical and biomechanical characteristics to...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to elucidate the underlying molecular mechanisms of cellular mechanosensitivity. The $387,662 award to Duke University will enable the development of novel biosensors and techniques to investigate how mechanical forces and protein phosphorylation regulate the mechanical state and force transmission capabilities of key linker...
- This $398,598 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research on mechanosensing mechanisms in intestinal epithelial cells. The principal investigator will use super-resolution functional imaging and in vivo interactomic approaches to identify conserved molecular machineries that drive mechanochemical sensing in epithelial microvilli, investigate physiological...
- This $249,000 project grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to elucidate the epigenetic regulation of the extracellular matrix and virus-induced fibroblast activation. The research project, which will be conducted at Tufts University over a 3-year period from September 15, 2025 to September 14, 2028, seeks to advance the understanding of the molecular mechanisms...
This federal Project Grant award of $451,000 was provided by the National Institutes of Health (NIH) Office of Research Infrastructure Programs (ORIP) under the Research Infrastructure Programs (CFDA 93.351). The award will fund the development and validation of a series of novel mouse models at Rhode Island Hospital, a division of Lifespan Corporation, to investigate the role of mechanotransduction - the ability of cells to sense and respond to mechanical stimuli - in the pathogenesis of various diseases, including arteriosclerosis, cardiomyopathies, asthma, and cancer. The research aims to provide the scientific community with new tools to manipulate mechanotransduction as a novel therapeutic approach for treating these conditions. The award has a project period from September 1, 2025 to August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $451.0k | 8/1/25 |